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- W3141512116 abstract "Acute lymphoblastic leukemia (ALL) results from a clonal expansion of abnormal lymphoid progenitors of B cell (BCP-ALL) or T cell (T-ALL) origin that invade bone marrow, peripheral blood, and extramedullary sites. Leukemic cells, apart from their oncogene-driven ability to proliferate and avoid differentiation, also change the phenotype and function of innate and adaptive immune cells, leading to escape from the immune surveillance. In this review, we provide an overview of the genetic heterogeneity and treatment of BCP- and T-ALL. We outline the interactions of leukemic cells in the bone marrow microenvironment, mainly with mesenchymal stem cells and immune cells. We describe the mechanisms by which ALL cells escape from immune recognition and elimination by the immune system. We focus on the alterations in ALL cells, such as overexpression of ligands for various inhibitory receptors, including anti-phagocytic receptors on macrophages, NK cell inhibitory receptors, as well as T cell immune checkpoints. In addition, we describe how developing leukemia shapes the bone marrow microenvironment and alters the function of immune cells. Finally, we emphasize that an immunosuppressive microenvironment can reduce the efficacy of chemo- and immunotherapy and provide examples of preclinical studies showing strategies for improving ALL treatment by targeting these immunosuppressive interactions." @default.
- W3141512116 created "2021-04-13" @default.
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- W3141512116 creator A5077307369 @default.
- W3141512116 date "2021-03-26" @default.
- W3141512116 modified "2023-10-05" @default.
- W3141512116 title "Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia" @default.
- W3141512116 cites W1262816711 @default.
- W3141512116 cites W1507575667 @default.
- W3141512116 cites W1538902372 @default.
- W3141512116 cites W1561620987 @default.
- W3141512116 cites W1901988103 @default.
- W3141512116 cites W1909108525 @default.
- W3141512116 cites W1927467942 @default.
- W3141512116 cites W1966103694 @default.
- W3141512116 cites W1967233735 @default.
- W3141512116 cites W1969995434 @default.
- W3141512116 cites W1974607766 @default.
- W3141512116 cites W1974612137 @default.
- W3141512116 cites W1977271544 @default.
- W3141512116 cites W1984378291 @default.
- W3141512116 cites W1992317131 @default.
- W3141512116 cites W1992644927 @default.
- W3141512116 cites W1997565001 @default.
- W3141512116 cites W2006474456 @default.
- W3141512116 cites W2009596701 @default.
- W3141512116 cites W2010537392 @default.
- W3141512116 cites W2013177587 @default.
- W3141512116 cites W2014308267 @default.
- W3141512116 cites W2018641619 @default.
- W3141512116 cites W2020425041 @default.
- W3141512116 cites W2024968355 @default.
- W3141512116 cites W2028231801 @default.
- W3141512116 cites W2031452237 @default.
- W3141512116 cites W2038408021 @default.
- W3141512116 cites W2040986265 @default.
- W3141512116 cites W2041235830 @default.
- W3141512116 cites W2042120460 @default.
- W3141512116 cites W2042185775 @default.
- W3141512116 cites W2042450855 @default.
- W3141512116 cites W2043969722 @default.
- W3141512116 cites W2045664257 @default.
- W3141512116 cites W2067047023 @default.
- W3141512116 cites W2067219650 @default.
- W3141512116 cites W2073878519 @default.
- W3141512116 cites W2075441508 @default.
- W3141512116 cites W2079521785 @default.
- W3141512116 cites W2084278750 @default.
- W3141512116 cites W2087764276 @default.
- W3141512116 cites W2088772561 @default.
- W3141512116 cites W2089836937 @default.
- W3141512116 cites W2094366129 @default.
- W3141512116 cites W2095012072 @default.
- W3141512116 cites W2096649209 @default.
- W3141512116 cites W2102037549 @default.
- W3141512116 cites W2104750134 @default.
- W3141512116 cites W2105780433 @default.
- W3141512116 cites W2106728539 @default.
- W3141512116 cites W2117658534 @default.
- W3141512116 cites W2122006466 @default.
- W3141512116 cites W2124779570 @default.
- W3141512116 cites W2128189415 @default.
- W3141512116 cites W2130030995 @default.
- W3141512116 cites W2130309988 @default.
- W3141512116 cites W2130869560 @default.
- W3141512116 cites W2140380746 @default.
- W3141512116 cites W2145871366 @default.
- W3141512116 cites W2148226248 @default.
- W3141512116 cites W2148541202 @default.
- W3141512116 cites W2150426043 @default.
- W3141512116 cites W2155813163 @default.
- W3141512116 cites W2157937957 @default.
- W3141512116 cites W2159560463 @default.
- W3141512116 cites W2159744102 @default.
- W3141512116 cites W2162856391 @default.
- W3141512116 cites W2164018844 @default.
- W3141512116 cites W2164577736 @default.
- W3141512116 cites W2211008635 @default.
- W3141512116 cites W2261048911 @default.
- W3141512116 cites W2262617296 @default.
- W3141512116 cites W2336673742 @default.
- W3141512116 cites W2339658711 @default.
- W3141512116 cites W2344579102 @default.
- W3141512116 cites W2400439118 @default.
- W3141512116 cites W2403548554 @default.
- W3141512116 cites W2419639370 @default.
- W3141512116 cites W2460477750 @default.
- W3141512116 cites W2463613583 @default.
- W3141512116 cites W2471500324 @default.
- W3141512116 cites W2496398835 @default.
- W3141512116 cites W2513620066 @default.
- W3141512116 cites W2520574697 @default.
- W3141512116 cites W2520695016 @default.
- W3141512116 cites W2521731346 @default.
- W3141512116 cites W2526303060 @default.