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- W3141518427 abstract "SUMMARY Background: The role of antibiotic therapy on Salmonella faecal excretion is controversial. Acute Salmonella gastroenteritis induces long-lasting digestive symptoms in up to one-third of subjects. The role of antimicrobial therapy on persistent post-infectious symptoms is unknown. Aim: To investigate the role of antibiotic therapy on long-term germ faecal excretion and digestive symptoms after Salmonella infection. Subjects and methods: 1543 subjects [518 aged between 3 and 5 years (35.3%); 950 between 6 and 10 years (64.7%) and 75 adults (4.9%)] involved in a single outbreak of Salmonella enteritis fulfilled the study criteria by repeating stool cultures and answering a symptom questionnaire 3 months post-infection. Results: 327 subjects (21.2%) were treated with antibiotics during the acute infection [121 children aged 3‐5 years (23.4%), 175 children aged 6‐10 years (18.4%) and 31 adults (41.3%)]. Antibiotic treatment did not affect Salmonella excretion at any of the time points studied up to three months post-infection in any age group as compared to age-matched untreated controls. Persistent digestive symptoms were more common among the patients treated with antibiotics (9.5% vs. 2.9%; Pa 0.003). Conclusions: Antibiotic therapy does not affect Salmonella enteritis excretion. Digestive symptoms after clearance of the infectious agent are significantly higher in patients treated with antibiotics during acute gastroenteritis." @default.
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- W3141518427 date "2000-01-01" @default.
- W3141518427 modified "2023-09-27" @default.
- W3141518427 title "Role of antibiotic therapy on long-term germ excretion in faeces and digestive symptoms after Salmonella infection" @default.
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