Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141519837> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3141519837 endingPage "1055" @default.
- W3141519837 startingPage "1049" @default.
- W3141519837 abstract "Matrine 被使用了在反煽动性并且反癌症治疗很长时间。然而，在 colorectal 癌症(CRC ) 的反变形的效果和相关机制仍然是不清楚的。在这研究，我们调查了 matrine 的管理是否能经由调整表明小径的 p38 禁止人的 CRC 房间的增长，活动性，和侵略。结果证明 matrine 在 vitro 并且在 vivo 禁止了 CRC 房间的移植和侵略。在为 24 h 与 matrine 被对待以后，另外，表示在 CRC 房间矩阵 metalloproteinase-2 (MMP-2 ) 和 MMP-9 以及朊酶活动铺平以一种剂量依赖者方式被减少。而且， matrine 显然减少了 p38 的 phosphorylation 水平。有 p38 禁止者(SB203580 ) 和 matrine 的联合治疗在 CRC 房间导致了侵略以及 MMP-2/-9 表示的 synergistic 减小。matrine 在 vivo 禁止了 CRC 肿瘤的增长和转移，这也被发现。在结论， p38 发信号小径可以由减少 MMP-2/-9 的表示在 CRC 房间的移植和侵略上在 matrine 的禁止的效果包含，建议 matrine 可以是为 CRC 的一个潜在的治疗学的代理人。" @default.
- W3141519837 created "2021-04-13" @default.
- W3141519837 creator A5001978013 @default.
- W3141519837 creator A5014610147 @default.
- W3141519837 creator A5017329591 @default.
- W3141519837 creator A5022476919 @default.
- W3141519837 creator A5025879011 @default.
- W3141519837 creator A5032245741 @default.
- W3141519837 creator A5037474620 @default.
- W3141519837 creator A5040402898 @default.
- W3141519837 creator A5050959776 @default.
- W3141519837 creator A5060325427 @default.
- W3141519837 creator A5061986938 @default.
- W3141519837 creator A5068421189 @default.
- W3141519837 date "2014-01-01" @default.
- W3141519837 modified "2023-09-23" @default.
- W3141519837 title "Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway" @default.
- W3141519837 hasPublicationYear "2014" @default.
- W3141519837 type Work @default.
- W3141519837 sameAs 3141519837 @default.
- W3141519837 citedByCount "0" @default.
- W3141519837 crossrefType "journal-article" @default.
- W3141519837 hasAuthorship W3141519837A5001978013 @default.
- W3141519837 hasAuthorship W3141519837A5014610147 @default.
- W3141519837 hasAuthorship W3141519837A5017329591 @default.
- W3141519837 hasAuthorship W3141519837A5022476919 @default.
- W3141519837 hasAuthorship W3141519837A5025879011 @default.
- W3141519837 hasAuthorship W3141519837A5032245741 @default.
- W3141519837 hasAuthorship W3141519837A5037474620 @default.
- W3141519837 hasAuthorship W3141519837A5040402898 @default.
- W3141519837 hasAuthorship W3141519837A5050959776 @default.
- W3141519837 hasAuthorship W3141519837A5060325427 @default.
- W3141519837 hasAuthorship W3141519837A5061986938 @default.
- W3141519837 hasAuthorship W3141519837A5068421189 @default.
- W3141519837 hasConcept C109523444 @default.
- W3141519837 hasConcept C118552586 @default.
- W3141519837 hasConcept C11960822 @default.
- W3141519837 hasConcept C121608353 @default.
- W3141519837 hasConcept C126322002 @default.
- W3141519837 hasConcept C150903083 @default.
- W3141519837 hasConcept C185592680 @default.
- W3141519837 hasConcept C207001950 @default.
- W3141519837 hasConcept C2776545273 @default.
- W3141519837 hasConcept C502942594 @default.
- W3141519837 hasConcept C51551487 @default.
- W3141519837 hasConcept C526805850 @default.
- W3141519837 hasConcept C55493867 @default.
- W3141519837 hasConcept C71924100 @default.
- W3141519837 hasConcept C86803240 @default.
- W3141519837 hasConcept C97029542 @default.
- W3141519837 hasConcept C98274493 @default.
- W3141519837 hasConceptScore W3141519837C109523444 @default.
- W3141519837 hasConceptScore W3141519837C118552586 @default.
- W3141519837 hasConceptScore W3141519837C11960822 @default.
- W3141519837 hasConceptScore W3141519837C121608353 @default.
- W3141519837 hasConceptScore W3141519837C126322002 @default.
- W3141519837 hasConceptScore W3141519837C150903083 @default.
- W3141519837 hasConceptScore W3141519837C185592680 @default.
- W3141519837 hasConceptScore W3141519837C207001950 @default.
- W3141519837 hasConceptScore W3141519837C2776545273 @default.
- W3141519837 hasConceptScore W3141519837C502942594 @default.
- W3141519837 hasConceptScore W3141519837C51551487 @default.
- W3141519837 hasConceptScore W3141519837C526805850 @default.
- W3141519837 hasConceptScore W3141519837C55493867 @default.
- W3141519837 hasConceptScore W3141519837C71924100 @default.
- W3141519837 hasConceptScore W3141519837C86803240 @default.
- W3141519837 hasConceptScore W3141519837C97029542 @default.
- W3141519837 hasConceptScore W3141519837C98274493 @default.
- W3141519837 hasIssue "12" @default.
- W3141519837 hasLocation W31415198371 @default.
- W3141519837 hasOpenAccess W3141519837 @default.
- W3141519837 hasPrimaryLocation W31415198371 @default.
- W3141519837 hasRelatedWork W1622087010 @default.
- W3141519837 hasRelatedWork W2006732248 @default.
- W3141519837 hasRelatedWork W2023153709 @default.
- W3141519837 hasRelatedWork W2045269572 @default.
- W3141519837 hasRelatedWork W2071482736 @default.
- W3141519837 hasRelatedWork W2526291696 @default.
- W3141519837 hasRelatedWork W2604490519 @default.
- W3141519837 hasRelatedWork W2748581418 @default.
- W3141519837 hasRelatedWork W2889213610 @default.
- W3141519837 hasRelatedWork W2889317640 @default.
- W3141519837 hasRelatedWork W2955670399 @default.
- W3141519837 hasRelatedWork W3014744250 @default.
- W3141519837 hasRelatedWork W3024185341 @default.
- W3141519837 hasRelatedWork W3033244365 @default.
- W3141519837 hasRelatedWork W3140349684 @default.
- W3141519837 hasRelatedWork W3141165170 @default.
- W3141519837 hasRelatedWork W3145006098 @default.
- W3141519837 hasRelatedWork W3168177080 @default.
- W3141519837 hasRelatedWork W3173462184 @default.
- W3141519837 hasRelatedWork W3185590525 @default.
- W3141519837 isParatext "false" @default.
- W3141519837 isRetracted "false" @default.
- W3141519837 magId "3141519837" @default.
- W3141519837 workType "article" @default.