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• W3141526209 abstract "We describe a low molecular weight covalent inhibitor targeting a conserved lysine residue within the hydrophobic pocket of HIV-1 glycoprotein-41. The inhibitor bound selectively to the hydrophobic pocket and exhibited an order of magnitude enhancement of anti-fusion activity against HIV-1 compared to its non-covalent counterpart. The findings represent a significant advance in the quest to obtain non-peptide fusion inhibitors." @default.
• W3141526209 created "2021-04-13" @default.
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• W3141526209 date "2021-01-01" @default.
• W3141526209 modified "2023-10-18" @default.
• W3141526209 title "A targeted covalent small molecule inhibitor of HIV-1 fusion" @default.
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• W3141526209 doi "https://doi.org/10.1039/d1cc01013a" @default.
• W3141526209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8141304" @default.
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