Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141526250> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3141526250 endingPage "917" @default.
- W3141526250 startingPage "911" @default.
- W3141526250 abstract "动脉粥样硬化是长期的煽动性的疾病。像使用费的受体(TLR4 ) 4 是重要发信号受体并且在煽动性的反应起一个关键作用。Poly (自动数据处理核糖)(PARP1 ) 聚合酶 1 是能调整各种各样的煽动性的基因的表示的原子酶。在这研究，我们调查了角色， lipopolysaccharide (LPS ) 上的 PARP1 的内在的机制在人的大动脉的 endothelial 房间导致了发炎。与控制相比， LPS 刺激增加了 TLR4 和 PARP1 的蛋白质表达式。TLR4 抑制象 PARP1 一样减少了可诱导的氮的氧化物 synthase (iNOS ) 和 ICAM-1 的导致 LPS 的 upregulation。原子因素 B (NF-B ) 抑制减少了 ICAM-1 和 iNOS 表示。PARP1 的抑制减少了煽动性的 cytokines 的蛋白质表示由 LPS 刺激导致了，可能通过阻止 NF-B 原子 translocation。我们的学习证明 LPS 经由 TLR4/PARP1/NF-B 小径增加了 ICAM-1 和 iNOS 表示。PARP1 可能是在在 LPS 刺激以后的调停 TLR4 的发炎的一个不可缺少的因素。PARP1 抑制可能在动脉粥样硬化期间使导致 LPS 的煽动性的 cytokines 表示的处理清楚些。" @default.
- W3141526250 created "2021-04-13" @default.
- W3141526250 creator A5001978013 @default.
- W3141526250 creator A5036241169 @default.
- W3141526250 creator A5051552423 @default.
- W3141526250 creator A5053780153 @default.
- W3141526250 creator A5060073997 @default.
- W3141526250 creator A5066727791 @default.
- W3141526250 date "2012-01-01" @default.
- W3141526250 modified "2023-09-23" @default.
- W3141526250 title "Poly（ADP-ribose） polymerase 1 inhibition protects human aortic endothelial cells against LPS-induced inflammation response" @default.
- W3141526250 hasPublicationYear "2012" @default.
- W3141526250 type Work @default.
- W3141526250 sameAs 3141526250 @default.
- W3141526250 citedByCount "0" @default.
- W3141526250 crossrefType "journal-article" @default.
- W3141526250 hasAuthorship W3141526250A5001978013 @default.
- W3141526250 hasAuthorship W3141526250A5036241169 @default.
- W3141526250 hasAuthorship W3141526250A5051552423 @default.
- W3141526250 hasAuthorship W3141526250A5053780153 @default.
- W3141526250 hasAuthorship W3141526250A5060073997 @default.
- W3141526250 hasAuthorship W3141526250A5066727791 @default.
- W3141526250 hasConcept C164027704 @default.
- W3141526250 hasConcept C17991360 @default.
- W3141526250 hasConcept C181199279 @default.
- W3141526250 hasConcept C182979987 @default.
- W3141526250 hasConcept C185592680 @default.
- W3141526250 hasConcept C203014093 @default.
- W3141526250 hasConcept C2776070231 @default.
- W3141526250 hasConcept C2776914184 @default.
- W3141526250 hasConcept C2777730290 @default.
- W3141526250 hasConcept C2778480876 @default.
- W3141526250 hasConcept C2778754761 @default.
- W3141526250 hasConcept C55493867 @default.
- W3141526250 hasConcept C82381507 @default.
- W3141526250 hasConcept C86803240 @default.
- W3141526250 hasConcept C98274493 @default.
- W3141526250 hasConceptScore W3141526250C164027704 @default.
- W3141526250 hasConceptScore W3141526250C17991360 @default.
- W3141526250 hasConceptScore W3141526250C181199279 @default.
- W3141526250 hasConceptScore W3141526250C182979987 @default.
- W3141526250 hasConceptScore W3141526250C185592680 @default.
- W3141526250 hasConceptScore W3141526250C203014093 @default.
- W3141526250 hasConceptScore W3141526250C2776070231 @default.
- W3141526250 hasConceptScore W3141526250C2776914184 @default.
- W3141526250 hasConceptScore W3141526250C2777730290 @default.
- W3141526250 hasConceptScore W3141526250C2778480876 @default.
- W3141526250 hasConceptScore W3141526250C2778754761 @default.
- W3141526250 hasConceptScore W3141526250C55493867 @default.
- W3141526250 hasConceptScore W3141526250C82381507 @default.
- W3141526250 hasConceptScore W3141526250C86803240 @default.
- W3141526250 hasConceptScore W3141526250C98274493 @default.
- W3141526250 hasIssue "11" @default.
- W3141526250 hasLocation W31415262501 @default.
- W3141526250 hasOpenAccess W3141526250 @default.
- W3141526250 hasPrimaryLocation W31415262501 @default.
- W3141526250 hasRelatedWork W2014484730 @default.
- W3141526250 hasRelatedWork W2070406983 @default.
- W3141526250 hasRelatedWork W2092629458 @default.
- W3141526250 hasRelatedWork W2122555550 @default.
- W3141526250 hasRelatedWork W2333450069 @default.
- W3141526250 hasRelatedWork W2594908340 @default.
- W3141526250 hasRelatedWork W2608412860 @default.
- W3141526250 hasRelatedWork W2767384814 @default.
- W3141526250 hasRelatedWork W2801963336 @default.
- W3141526250 hasRelatedWork W2802588821 @default.
- W3141526250 hasRelatedWork W2921531782 @default.
- W3141526250 hasRelatedWork W2923133373 @default.
- W3141526250 hasRelatedWork W2953865681 @default.
- W3141526250 hasRelatedWork W2990073535 @default.
- W3141526250 hasRelatedWork W2992137244 @default.
- W3141526250 hasRelatedWork W2998716892 @default.
- W3141526250 hasRelatedWork W3031572820 @default.
- W3141526250 hasRelatedWork W3125489611 @default.
- W3141526250 hasRelatedWork W3148200953 @default.
- W3141526250 hasRelatedWork W3151430013 @default.
- W3141526250 hasVolume "44" @default.
- W3141526250 isParatext "false" @default.
- W3141526250 isRetracted "false" @default.
- W3141526250 magId "3141526250" @default.
- W3141526250 workType "article" @default.