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• W3141530841 abstract "MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究，我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地， CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated，和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且，二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated，并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起，我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素，并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。" @default.
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• W3141530841 date "2014-01-01" @default.
• W3141530841 modified "2023-09-24" @default.
• W3141530841 title "MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1" @default.
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