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- W3141539225 abstract "Objective To study the effect of Chinese herbal compound (CHC) on the expression of hepatocyte cytochrome P450IIE1 in rat model of alcoholic fatty liver (AFL). Methods The AFL rats models were established by administrating the drinking water with 40%(v/v) ehtanol, and the changes of pathology in liver and hepatocyte P450IIE1 expression, as well as the contents of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione(GSH), vitamine E (VitE) in liver were detected and compared with those in the control group. Results Fatty degeneration in liver recovered normally in the CHC-treated group. Immunohistochemical and in situ hybridization examination showed that CHC could inhibit the hepatocyte cytochrome P450IIE1 expression markedly, and restore the contents of MDA, SOD, GSH, VitE to nearly normal range. Conclusion CHC can prevent AFL through inhibiting the hepatocyte cytochrome P450IIE1 expression markedly." @default.
- W3141539225 created "2021-04-13" @default.
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- W3141539225 date "2003-01-01" @default.
- W3141539225 modified "2023-09-28" @default.
- W3141539225 title "Effects of Chinese herbal compound on the expression of hepatocyte cytochrome P450IIE_1 in rats with alcoholic fatty liver" @default.
- W3141539225 hasPublicationYear "2003" @default.
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