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- W3141549069 abstract "The Akirin gene is a recently discovered to plays important roles in regulation of immune and inflammatory response,as well as in the myogenesis in Drosophila and mice.In this study,the full-length Akirin gene in Hi-Line Brown chicken was cloned using an in silico approach.The sequence homology and protein functions of chicken Akirin were predicted using bioinformatic analysis,and the tissue expression pattern was investigated using semi-quantitative RT-PCR in both the newly hatched and adult chicken.The full-length coding sequence of chicken Akirin gene is 576 bp and conserved evolutionally.The Akirin protein sequence is predicted to have several functional domains,including PFAM,RGS,TOP1Bc,UTG,HMG and some low complexity sequence.Three sites as the protein kinase C phosphorylation,tyrosine kinase phosphorylation,N-myristoylation can also be found in the amino acid sequence.One predicted microRNA targeting site was identified in the 3′ untranslated region of chicken Akirin mRNA.The Akirin expression was detected in a variety of organizations,such as heart,spleen,brain,etc.Our results suggested that chicken Akirin might be a novel gene with multiple functions." @default.
- W3141549069 created "2021-04-13" @default.
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- W3141549069 date "2011-01-01" @default.
- W3141549069 modified "2023-09-25" @default.
- W3141549069 title "Cloning and Tissue Expression Analysis of Chicken Akirin Homologous Gene" @default.
- W3141549069 hasPublicationYear "2011" @default.
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