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- W3141550142 abstract "This study was carried out to elucidate the effects of calcium independent phospholipase A2 (iPLA2) on mitochondrial function and exocytosis in neuroendo- crine cells. iPLA2 mRNA and protein were detected in cell lysates and mitochondria from PC12 cells. Treatment of cells with the iPLA2 inhibitor, bromoenol lactone (BEL), resulted in reduction in the mitochondrial membrane potential. Increase in membrane capacitance and number of spikes at amperometry, indicating exocytosis, were detec- ted from PC12 cells after treatment with BEL. The induced exocytosis was abolished by pre-incubation of cells with the antioxidant, glutathione monoethyl ester, spin-trap/free radical scavenger, PBN, or inhibitors of the mitochondrial permeability transition pore, cyclosporine A and bon- gkrekic acid. These findings indicate that inhibition of iPLA2 results in excessive exocytosis through increased oxidative damage (or failure to repair such damage) and defects in mitochondrial function. A similar process may occur in neurons with mutations in iPLA2, leading to neuronal injury." @default.
- W3141550142 created "2021-04-13" @default.
- W3141550142 creator A5018303911 @default.
- W3141550142 date "2011-01-01" @default.
- W3141550142 modified "2023-09-24" @default.
- W3141550142 title "Role of Calcium Independent Phospholipase A 2 in Maintaining Mitochondrial Membrane Potential and Preventing Excessive Exocytosis in PC12 Cells" @default.
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