Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141554997> ?p ?o ?g. }
- W3141554997 abstract "Abstract Epilepsy is one of the most common diseases of the central nervous system globally. To ensure the correct dosage of antiepileptic treatment, it is helpful to check the blood levels of the administered substances regularly. The analysis of the capillary dried blood samples provides a promising and less‐invasive alternative to venous blood collection. Therefore, the aim of the present study was to develop an LC–MS method for the quantification of 22 commonly used drugs in patients with an epileptic syndrome and 5 drug metabolites in one dried blood spot (DBS). The calibration ranges were selected in such a way that the therapeutic reference ranges in serum for the respective substances were completely covered. The analytical validation was successfully performed according to relevant guidelines with a consideration of requirements for DBS analysis. Proof of concept of the developed method was obtained by the analysis of DBSs from 282 authentic leftover ethylenediaminetetraacetic acid blood samples, which were compared with the corresponding serum concentrations. Altogether, the results show a dependency on the blood/plasma (b/p) ratios of the respective analytes so that for drugs with b/p ratios close to one, for example, lacosamide, levetiracetam, brivaracetam, and sertraline, a good accordance was observed." @default.
- W3141554997 created "2021-04-13" @default.
- W3141554997 creator A5067925206 @default.
- W3141554997 creator A5072656678 @default.
- W3141554997 creator A5078538073 @default.
- W3141554997 creator A5088008661 @default.
- W3141554997 creator A5091496081 @default.
- W3141554997 date "2021-04-21" @default.
- W3141554997 modified "2023-10-01" @default.
- W3141554997 title "Development and validation of an LC–MS/MS method for relevant drugs in epilepsy patients using dried blood spots" @default.
- W3141554997 cites W1700762969 @default.
- W3141554997 cites W1890699301 @default.
- W3141554997 cites W1979411124 @default.
- W3141554997 cites W2011602524 @default.
- W3141554997 cites W2032655978 @default.
- W3141554997 cites W2042516926 @default.
- W3141554997 cites W2043432221 @default.
- W3141554997 cites W2048718351 @default.
- W3141554997 cites W2060587811 @default.
- W3141554997 cites W2065782446 @default.
- W3141554997 cites W2065919676 @default.
- W3141554997 cites W2070280207 @default.
- W3141554997 cites W2084700873 @default.
- W3141554997 cites W2091011251 @default.
- W3141554997 cites W2091251586 @default.
- W3141554997 cites W2141982413 @default.
- W3141554997 cites W2286021468 @default.
- W3141554997 cites W2314798820 @default.
- W3141554997 cites W2372510539 @default.
- W3141554997 cites W2524589090 @default.
- W3141554997 cites W2595095683 @default.
- W3141554997 cites W2603415173 @default.
- W3141554997 cites W2736106459 @default.
- W3141554997 cites W2748972541 @default.
- W3141554997 cites W2753966476 @default.
- W3141554997 cites W2766111788 @default.
- W3141554997 cites W2766215164 @default.
- W3141554997 cites W2788348875 @default.
- W3141554997 cites W2792396946 @default.
- W3141554997 cites W2914989841 @default.
- W3141554997 cites W2932723690 @default.
- W3141554997 cites W2945510054 @default.
- W3141554997 cites W2951212575 @default.
- W3141554997 cites W2952961655 @default.
- W3141554997 cites W2954012220 @default.
- W3141554997 cites W2979836558 @default.
- W3141554997 cites W3003535682 @default.
- W3141554997 cites W3011553004 @default.
- W3141554997 cites W4248509643 @default.
- W3141554997 doi "https://doi.org/10.1002/bmc.5130" @default.
- W3141554997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33780026" @default.
- W3141554997 hasPublicationYear "2021" @default.
- W3141554997 type Work @default.
- W3141554997 sameAs 3141554997 @default.
- W3141554997 citedByCount "4" @default.
- W3141554997 countsByYear W31415549972023 @default.
- W3141554997 crossrefType "journal-article" @default.
- W3141554997 hasAuthorship W3141554997A5067925206 @default.
- W3141554997 hasAuthorship W3141554997A5072656678 @default.
- W3141554997 hasAuthorship W3141554997A5078538073 @default.
- W3141554997 hasAuthorship W3141554997A5088008661 @default.
- W3141554997 hasAuthorship W3141554997A5091496081 @default.
- W3141554997 hasConcept C118552586 @default.
- W3141554997 hasConcept C185592680 @default.
- W3141554997 hasConcept C194828623 @default.
- W3141554997 hasConcept C2776597655 @default.
- W3141554997 hasConcept C2777332695 @default.
- W3141554997 hasConcept C2778139780 @default.
- W3141554997 hasConcept C2778186239 @default.
- W3141554997 hasConcept C2780035454 @default.
- W3141554997 hasConcept C2780272996 @default.
- W3141554997 hasConcept C2994091943 @default.
- W3141554997 hasConcept C43617362 @default.
- W3141554997 hasConcept C71924100 @default.
- W3141554997 hasConcept C98274493 @default.
- W3141554997 hasConceptScore W3141554997C118552586 @default.
- W3141554997 hasConceptScore W3141554997C185592680 @default.
- W3141554997 hasConceptScore W3141554997C194828623 @default.
- W3141554997 hasConceptScore W3141554997C2776597655 @default.
- W3141554997 hasConceptScore W3141554997C2777332695 @default.
- W3141554997 hasConceptScore W3141554997C2778139780 @default.
- W3141554997 hasConceptScore W3141554997C2778186239 @default.
- W3141554997 hasConceptScore W3141554997C2780035454 @default.
- W3141554997 hasConceptScore W3141554997C2780272996 @default.
- W3141554997 hasConceptScore W3141554997C2994091943 @default.
- W3141554997 hasConceptScore W3141554997C43617362 @default.
- W3141554997 hasConceptScore W3141554997C71924100 @default.
- W3141554997 hasConceptScore W3141554997C98274493 @default.
- W3141554997 hasIssue "9" @default.
- W3141554997 hasLocation W31415549971 @default.
- W3141554997 hasOpenAccess W3141554997 @default.
- W3141554997 hasPrimaryLocation W31415549971 @default.
- W3141554997 hasRelatedWork W2058427958 @default.
- W3141554997 hasRelatedWork W2537478391 @default.
- W3141554997 hasRelatedWork W2742158623 @default.
- W3141554997 hasRelatedWork W2952961655 @default.
- W3141554997 hasRelatedWork W3002439210 @default.
- W3141554997 hasRelatedWork W3126856367 @default.
- W3141554997 hasRelatedWork W3141554997 @default.
- W3141554997 hasRelatedWork W3154702922 @default.