Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141559382> ?p ?o ?g. }
- W3141559382 endingPage "104884" @default.
- W3141559382 startingPage "104884" @default.
- W3141559382 abstract "The objective of this study was to discover potential topoisomerase (topo) targeting anticancer agents. Novel series of hydroxylated and halogenated(-F, -Cl, and -CF3) 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols were systematically designed and synthesized by faster, economic, and environmentally friendly l-proline catalyzed and microwave-assisted one pot reaction method. The synthesized compounds were assessed for topo I and IIα inhibitory and anti-proliferative activities. The in vitroevaluation displayed that most of the compounds have selective topo IIα inhibitoryactivity as well as selectivity towards T47D human cancer cell line. Structure-activity relationship study suggested that the introduction of additional hydroxyl functionality at 7-positon of benzofuro[3,2-b]pyridine skeleton is crucial for selective topo IIα inhibitory activity. Placement of phenolic moiety on the 4-position of the tricyclic system imparts better topo IIα inhibitory and anti-proliferative activity." @default.
- W3141559382 created "2021-04-13" @default.
- W3141559382 creator A5000910069 @default.
- W3141559382 creator A5016353397 @default.
- W3141559382 creator A5033090781 @default.
- W3141559382 creator A5034172710 @default.
- W3141559382 creator A5038483135 @default.
- W3141559382 creator A5047995856 @default.
- W3141559382 creator A5061298783 @default.
- W3141559382 creator A5062543970 @default.
- W3141559382 date "2021-06-01" @default.
- W3141559382 modified "2023-09-23" @default.
- W3141559382 title "Synthesis and structure-activity relationships of hydroxylated and halogenated 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols as selective topoisomerase IIα inhibitors" @default.
- W3141559382 cites W1173959259 @default.
- W3141559382 cites W1498953001 @default.
- W3141559382 cites W1512072225 @default.
- W3141559382 cites W1595025564 @default.
- W3141559382 cites W1982346259 @default.
- W3141559382 cites W2000165665 @default.
- W3141559382 cites W2026155624 @default.
- W3141559382 cites W2056441912 @default.
- W3141559382 cites W2056657908 @default.
- W3141559382 cites W2069057836 @default.
- W3141559382 cites W2069931511 @default.
- W3141559382 cites W2099090001 @default.
- W3141559382 cites W2124624490 @default.
- W3141559382 cites W2135469082 @default.
- W3141559382 cites W2142716713 @default.
- W3141559382 cites W2152576550 @default.
- W3141559382 cites W2203169492 @default.
- W3141559382 cites W2571061950 @default.
- W3141559382 cites W2619821384 @default.
- W3141559382 cites W2623976775 @default.
- W3141559382 cites W2789302862 @default.
- W3141559382 cites W2789505416 @default.
- W3141559382 cites W2946697697 @default.
- W3141559382 cites W2976394500 @default.
- W3141559382 cites W2978697046 @default.
- W3141559382 cites W2982595724 @default.
- W3141559382 cites W2999230201 @default.
- W3141559382 cites W3012055614 @default.
- W3141559382 cites W3045235012 @default.
- W3141559382 cites W2961567173 @default.
- W3141559382 doi "https://doi.org/10.1016/j.bioorg.2021.104884" @default.
- W3141559382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33872925" @default.
- W3141559382 hasPublicationYear "2021" @default.
- W3141559382 type Work @default.
- W3141559382 sameAs 3141559382 @default.
- W3141559382 citedByCount "3" @default.
- W3141559382 countsByYear W31415593822021 @default.
- W3141559382 countsByYear W31415593822022 @default.
- W3141559382 countsByYear W31415593822023 @default.
- W3141559382 crossrefType "journal-article" @default.
- W3141559382 hasAuthorship W3141559382A5000910069 @default.
- W3141559382 hasAuthorship W3141559382A5016353397 @default.
- W3141559382 hasAuthorship W3141559382A5033090781 @default.
- W3141559382 hasAuthorship W3141559382A5034172710 @default.
- W3141559382 hasAuthorship W3141559382A5038483135 @default.
- W3141559382 hasAuthorship W3141559382A5047995856 @default.
- W3141559382 hasAuthorship W3141559382A5061298783 @default.
- W3141559382 hasAuthorship W3141559382A5062543970 @default.
- W3141559382 hasConcept C118792377 @default.
- W3141559382 hasConcept C121608353 @default.
- W3141559382 hasConcept C126322002 @default.
- W3141559382 hasConcept C147897179 @default.
- W3141559382 hasConcept C155647269 @default.
- W3141559382 hasConcept C161790260 @default.
- W3141559382 hasConcept C169760540 @default.
- W3141559382 hasConcept C17077164 @default.
- W3141559382 hasConcept C181199279 @default.
- W3141559382 hasConcept C185592680 @default.
- W3141559382 hasConcept C193042331 @default.
- W3141559382 hasConcept C202751555 @default.
- W3141559382 hasConcept C21951064 @default.
- W3141559382 hasConcept C2776568683 @default.
- W3141559382 hasConcept C2779485729 @default.
- W3141559382 hasConcept C2781081902 @default.
- W3141559382 hasConcept C2994372470 @default.
- W3141559382 hasConcept C55493867 @default.
- W3141559382 hasConcept C71240020 @default.
- W3141559382 hasConcept C71924100 @default.
- W3141559382 hasConcept C86803240 @default.
- W3141559382 hasConcept C96232424 @default.
- W3141559382 hasConceptScore W3141559382C118792377 @default.
- W3141559382 hasConceptScore W3141559382C121608353 @default.
- W3141559382 hasConceptScore W3141559382C126322002 @default.
- W3141559382 hasConceptScore W3141559382C147897179 @default.
- W3141559382 hasConceptScore W3141559382C155647269 @default.
- W3141559382 hasConceptScore W3141559382C161790260 @default.
- W3141559382 hasConceptScore W3141559382C169760540 @default.
- W3141559382 hasConceptScore W3141559382C17077164 @default.
- W3141559382 hasConceptScore W3141559382C181199279 @default.
- W3141559382 hasConceptScore W3141559382C185592680 @default.
- W3141559382 hasConceptScore W3141559382C193042331 @default.
- W3141559382 hasConceptScore W3141559382C202751555 @default.
- W3141559382 hasConceptScore W3141559382C21951064 @default.
- W3141559382 hasConceptScore W3141559382C2776568683 @default.
- W3141559382 hasConceptScore W3141559382C2779485729 @default.