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• W3141565208 abstract "RNA-binding motif protein, X-linked (RBMX) is a 43 kDa nuclear protein in the RBM family and func- tions on alternative splicing of RNA. The gene encoding RBMX is located on chromosome Xq26. To investigate whether RBMX is involved in retinal neuron apoptosis, we performed a light-induced retinal damage model in adult rats. Western blotting analysis showed RBMX gradually increased, reached a peak at 12 h and then declined during the following days. The association of RBMX in retinal ganglion cells (RGCs) with light exposure was found by immunofluorescence staining. The injury-induced expres- sion of RBMX was detected in active caspase-3 and TUNEL positive cells. We also examined the expression profiles of active caspase-3, bcl-2 and Bax, whose changes were correlated with the expression profiles of RBMX. To summarize, we uncovered the dynamic changes of RBMX in the light-induced retinal damage model for the first time. RBMX might play a significant role in the degenerative process of RGCs after light-induced damage in the retina." @default.
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• W3141565208 date "2015-01-01" @default.
• W3141565208 modified "2023-09-26" @default.
• W3141565208 title "Expression of RBMX in the Light-Induced Damage of Rat Retina In Vivo" @default.
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