Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141571013> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3141571013 endingPage "5724" @default.
- W3141571013 startingPage "5721" @default.
- W3141571013 abstract "AIM: To study the relationship of human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles with the genetic susceptibility to HBV infection and the response to interferon (IFN) in HBV-infected patients.METHODS: Low-resolution DNA typing kit was used to determine HLA-DR-1 and -DQB1 genes in 72 patients with chronic hepatitis B (CHB) and HLA-DRB1 in 200 healthy people ready to donate their bone marrow in Shanghai.Among CHB patients, 35 were treated with IFNα-1b for 24 wk.RESULTS: The frequencies of HLA-DRB1*06, DRB1*08and DRB1*16 alleles in 72 patients were higher than in 200 healthy people (2.08% vs0%, OR = 3.837, P= 0.018;11.11% vs5.50%, OR = 2.148, P= 0.034; and 6.94% vs 3.00%, OR = 0.625, P = 0.049, respectively); whereas that of DRB1*07 allele was lower (2.78% vs 7.75%,OR = 0.340, P = 0.046). The frequency of HLA-DRB1* 14allele was higher in 11 responders to IFN compared with 24 non-responders (18.18% vs2.08%, OR = 10.444,P = 0.031), whereas that of DQB1*07 allele was inverse (9.09% vs 37.50%, OR = 0.167, P= 0.021).CONCLUSION: The polymorphism of HLA class Ⅱ may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment.Compared with other HLA-DQB1 alleles, HLA-DQB1*07 may be associated with low response rate to IFN." @default.
- W3141571013 created "2021-04-13" @default.
- W3141571013 creator A5008108990 @default.
- W3141571013 creator A5008634555 @default.
- W3141571013 creator A5013442821 @default.
- W3141571013 creator A5055204758 @default.
- W3141571013 creator A5060073997 @default.
- W3141571013 creator A5066454165 @default.
- W3141571013 creator A5066562642 @default.
- W3141571013 creator A5069489564 @default.
- W3141571013 creator A5073161777 @default.
- W3141571013 creator A5083320053 @default.
- W3141571013 date "2005-01-01" @default.
- W3141571013 modified "2023-09-26" @default.
- W3141571013 title "Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients" @default.
- W3141571013 hasPublicationYear "2005" @default.
- W3141571013 type Work @default.
- W3141571013 sameAs 3141571013 @default.
- W3141571013 citedByCount "13" @default.
- W3141571013 countsByYear W31415710132012 @default.
- W3141571013 countsByYear W31415710132013 @default.
- W3141571013 countsByYear W31415710132014 @default.
- W3141571013 crossrefType "journal-article" @default.
- W3141571013 hasAuthorship W3141571013A5008108990 @default.
- W3141571013 hasAuthorship W3141571013A5008634555 @default.
- W3141571013 hasAuthorship W3141571013A5013442821 @default.
- W3141571013 hasAuthorship W3141571013A5055204758 @default.
- W3141571013 hasAuthorship W3141571013A5060073997 @default.
- W3141571013 hasAuthorship W3141571013A5066454165 @default.
- W3141571013 hasAuthorship W3141571013A5066562642 @default.
- W3141571013 hasAuthorship W3141571013A5069489564 @default.
- W3141571013 hasAuthorship W3141571013A5073161777 @default.
- W3141571013 hasAuthorship W3141571013A5083320053 @default.
- W3141571013 hasConcept C104317684 @default.
- W3141571013 hasConcept C147483822 @default.
- W3141571013 hasConcept C159047783 @default.
- W3141571013 hasConcept C180754005 @default.
- W3141571013 hasConcept C188280979 @default.
- W3141571013 hasConcept C203014093 @default.
- W3141571013 hasConcept C2522874641 @default.
- W3141571013 hasConcept C2776178377 @default.
- W3141571013 hasConcept C2780593183 @default.
- W3141571013 hasConcept C54355233 @default.
- W3141571013 hasConcept C71924100 @default.
- W3141571013 hasConcept C86803240 @default.
- W3141571013 hasConceptScore W3141571013C104317684 @default.
- W3141571013 hasConceptScore W3141571013C147483822 @default.
- W3141571013 hasConceptScore W3141571013C159047783 @default.
- W3141571013 hasConceptScore W3141571013C180754005 @default.
- W3141571013 hasConceptScore W3141571013C188280979 @default.
- W3141571013 hasConceptScore W3141571013C203014093 @default.
- W3141571013 hasConceptScore W3141571013C2522874641 @default.
- W3141571013 hasConceptScore W3141571013C2776178377 @default.
- W3141571013 hasConceptScore W3141571013C2780593183 @default.
- W3141571013 hasConceptScore W3141571013C54355233 @default.
- W3141571013 hasConceptScore W3141571013C71924100 @default.
- W3141571013 hasConceptScore W3141571013C86803240 @default.
- W3141571013 hasIssue "36" @default.
- W3141571013 hasLocation W31415710131 @default.
- W3141571013 hasOpenAccess W3141571013 @default.
- W3141571013 hasPrimaryLocation W31415710131 @default.
- W3141571013 hasRelatedWork W1695483257 @default.
- W3141571013 hasRelatedWork W1981387786 @default.
- W3141571013 hasRelatedWork W1982640402 @default.
- W3141571013 hasRelatedWork W2001186080 @default.
- W3141571013 hasRelatedWork W2004856792 @default.
- W3141571013 hasRelatedWork W2074197155 @default.
- W3141571013 hasRelatedWork W2097150100 @default.
- W3141571013 hasRelatedWork W2104736698 @default.
- W3141571013 hasRelatedWork W2223451815 @default.
- W3141571013 hasRelatedWork W2329292353 @default.
- W3141571013 hasRelatedWork W2359013331 @default.
- W3141571013 hasRelatedWork W2387602628 @default.
- W3141571013 hasRelatedWork W2397030104 @default.
- W3141571013 hasRelatedWork W2397916318 @default.
- W3141571013 hasRelatedWork W2409543920 @default.
- W3141571013 hasRelatedWork W2755378174 @default.
- W3141571013 hasRelatedWork W2769811547 @default.
- W3141571013 hasRelatedWork W2991414776 @default.
- W3141571013 hasRelatedWork W3022451238 @default.
- W3141571013 hasRelatedWork W2802348936 @default.
- W3141571013 hasVolume "11" @default.
- W3141571013 isParatext "false" @default.
- W3141571013 isRetracted "false" @default.
- W3141571013 magId "3141571013" @default.
- W3141571013 workType "article" @default.