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- W3141580383 abstract "In the past, clinical trials transplanting bone marrow-derived mononuclear cells reported a limited improvement in cardiac function. Therefore, the search for stem cells leading to more successful stem cell therapies continues. Good candidates are the so-called cardiac stem cells (CSCs). To date, there is no clear evidence to show if these cells are intrinsic stem cells from the heart or mobi- lized cells from bone marrow. In this study we performed a comparative study between human mesenchymal stem cells (hMSCs), purified c-kit ? CSCs, and cardiosphere-derived cells (CDCs). Our results showed that hMSCs can be dis- criminated from CSCs by their differentiation capacity towards adipocytes and osteocytes and the expression of CD140b. On the other hand, cardiac progenitors display a greater cardiomyogenic differentiation capacity. Despite a different isolation protocol, no distinction could be made between c-kit ? CSCs and CDCs, indicating that they probably derive from the same precursor or even are the same cells." @default.
- W3141580383 created "2021-04-13" @default.
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- W3141580383 date "2010-01-01" @default.
- W3141580383 modified "2023-09-23" @default.
- W3141580383 title "Mesenchymal stem cells or cardiac progenitors for cardiac repair? A comparative study" @default.
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