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- W3141581012 abstract "A synthetic analogue of hainanensine 2a was further modified in order to improveits antitumor activity. Six compounds 3～8,were obtained, and among these compounds 8 showedsignificant activity. The diastereomer (±)8B was resolved by (+) tartaric acid and (-)benzoyl-tartar-ic acid to the corresponding enantiomers (-)8B and (+)8B, respectively and their optical puritieswere determined by isotope dilution method as 93% and 96%.The antitumor activity of the newly obtained compounds were tested in vitro, and (-)8B wasfound to have an IC_(50) of 1.9 mol/L, eighteen times higher than the original compound 2a." @default.
- W3141581012 created "2021-04-13" @default.
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- W3141581012 date "1992-01-01" @default.
- W3141581012 modified "2023-09-26" @default.
- W3141581012 title "CHEMISTRY AND ANTITUMOR ACTIVITY OF HAINANENSINE ANALOGUES" @default.
- W3141581012 hasPublicationYear "1992" @default.
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