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- W3141594802 endingPage "4433" @default.
- W3141594802 startingPage "4417" @default.
- W3141594802 abstract "Retinal ganglion cells (RGCs) are the only projection neurons in the neural retina. They receive and integrate visual signals from upstream retinal neurons in the visual circuitry and transmit them to the brain. The function of RGCs is performed by the approximately 40 RGC types projecting to various central brain targets. RGCs are the first cell type to form during retinogenesis. The specification and differentiation of the RGC lineage is a stepwise process; a hierarchical gene regulatory network controlling the RGC lineage has been identified and continues to be elaborated. Recent studies with single-cell transcriptomics have led to unprecedented new insights into their types and developmental trajectory. In this review, we summarize our current understanding of the functions and relationships of the many regulators of the specification and differentiation of the RGC lineage. We emphasize the roles of these key transcription factors and pathways in different developmental steps, including the transition from retinal progenitor cells (RPCs) to RGCs, RGC differentiation, generation of diverse RGC types, and central projection of the RGC axons. We discuss critical issues that remain to be addressed for a comprehensive understanding of these different aspects of RGC genesis and emerging technologies, including single-cell techniques, novel genetic tools and resources, and high-throughput genome editing and screening assays, which can be leveraged in future studies." @default.
- W3141594802 created "2021-04-13" @default.
- W3141594802 creator A5041966486 @default.
- W3141594802 creator A5068006897 @default.
- W3141594802 date "2021-03-29" @default.
- W3141594802 modified "2023-10-10" @default.
- W3141594802 title "Genetic control of retinal ganglion cell genesis" @default.
- W3141594802 cites W1514835858 @default.
- W3141594802 cites W1821853514 @default.
- W3141594802 cites W1835721351 @default.
- W3141594802 cites W1895998181 @default.
- W3141594802 cites W1964163541 @default.
- W3141594802 cites W1969767584 @default.
- W3141594802 cites W1971636570 @default.
- W3141594802 cites W1972468954 @default.
- W3141594802 cites W1974565082 @default.
- W3141594802 cites W1974667208 @default.
- W3141594802 cites W1975728537 @default.
- W3141594802 cites W1976616514 @default.
- W3141594802 cites W1977949300 @default.
- W3141594802 cites W1977962361 @default.
- W3141594802 cites W1978148843 @default.
- W3141594802 cites W1979386469 @default.
- W3141594802 cites W1979440192 @default.
- W3141594802 cites W1980859816 @default.
- W3141594802 cites W1980980049 @default.
- W3141594802 cites W1982161960 @default.
- W3141594802 cites W1985657116 @default.
- W3141594802 cites W1985901090 @default.
- W3141594802 cites W1985912987 @default.
- W3141594802 cites W1988027093 @default.
- W3141594802 cites W1988939522 @default.
- W3141594802 cites W1989972710 @default.
- W3141594802 cites W1990122646 @default.
- W3141594802 cites W1990433739 @default.
- W3141594802 cites W1991420497 @default.
- W3141594802 cites W1994638701 @default.
- W3141594802 cites W1994750743 @default.
- W3141594802 cites W1995854663 @default.
- W3141594802 cites W1997801717 @default.
- W3141594802 cites W1997987643 @default.
- W3141594802 cites W1999254348 @default.
- W3141594802 cites W2000722876 @default.
- W3141594802 cites W2001472734 @default.
- W3141594802 cites W2004475101 @default.
- W3141594802 cites W2004632858 @default.
- W3141594802 cites W2006806808 @default.
- W3141594802 cites W2006948750 @default.
- W3141594802 cites W2007225104 @default.
- W3141594802 cites W2009787193 @default.
- W3141594802 cites W2009990282 @default.
- W3141594802 cites W2011341845 @default.
- W3141594802 cites W2013100732 @default.
- W3141594802 cites W2013741270 @default.
- W3141594802 cites W2015162112 @default.
- W3141594802 cites W2017350075 @default.
- W3141594802 cites W2017997282 @default.
- W3141594802 cites W2018936581 @default.
- W3141594802 cites W2019801732 @default.
- W3141594802 cites W2022863392 @default.
- W3141594802 cites W2023903464 @default.
- W3141594802 cites W2026591252 @default.
- W3141594802 cites W2030648800 @default.
- W3141594802 cites W2032751739 @default.
- W3141594802 cites W2033937556 @default.
- W3141594802 cites W2035806445 @default.
- W3141594802 cites W2037390777 @default.
- W3141594802 cites W2037603093 @default.
- W3141594802 cites W2038480702 @default.
- W3141594802 cites W2040399449 @default.
- W3141594802 cites W2040829596 @default.
- W3141594802 cites W2044091203 @default.
- W3141594802 cites W2045318076 @default.
- W3141594802 cites W2046728523 @default.
- W3141594802 cites W2048275890 @default.
- W3141594802 cites W2049279317 @default.
- W3141594802 cites W2050218188 @default.
- W3141594802 cites W2054733459 @default.
- W3141594802 cites W2055725555 @default.
- W3141594802 cites W2055968613 @default.
- W3141594802 cites W2057837809 @default.
- W3141594802 cites W2058483899 @default.
- W3141594802 cites W2059678501 @default.
- W3141594802 cites W2059679976 @default.
- W3141594802 cites W2060395602 @default.
- W3141594802 cites W2060997280 @default.
- W3141594802 cites W2061122481 @default.
- W3141594802 cites W2061683639 @default.
- W3141594802 cites W2063902684 @default.
- W3141594802 cites W2066187363 @default.
- W3141594802 cites W2070603983 @default.
- W3141594802 cites W2071255383 @default.
- W3141594802 cites W2075671933 @default.
- W3141594802 cites W2076721314 @default.
- W3141594802 cites W2076780019 @default.
- W3141594802 cites W2077383808 @default.
- W3141594802 cites W2077428235 @default.
- W3141594802 cites W2078186919 @default.