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- W3141654055 abstract "The present research assessed the effects of lettuce glycoside B (LGB), a compound separated and purified from Pterocypsela laciniata, on irradiation- induced pulmonary fibrosis and explored the mechanism involved. Animal model of irradiation exposure inducing pulmonary fibrosis was established by Co irradiator. Rats were intraperitoneally treated with LGB (100, 200 and 400 mg/kg) once per day for a month. Lung index data were analyzed. The levels of fibrosis were assessed by hydroxyproline (Hyp) of pulmonary and lung tissue sec- tions after irradiation exposure. Alveolitis and fibrosis levels were calculated from semi-quantitative analysis of hematoxylin and eosin and Masson's trichrome lung sec- tion staining. The serum levels of transforming growth factor b1 (TGF-b1), interleukin (IL)-6, and tumor necrosis factor-a (TNF-a) were also evaluated. Antioxidant enzymes of superoxide dismutase (SOD) were measured in serum. Moreover, we also measured serum malondialde- hyde (MDA) levels, a marker of oxidative stress. Treat- ment with LGB significantly reduced mortality rates and lung index scores and MDA content, enhanced SOD and other antioxidant enzymes activity, and regulated serum levels of TGF-b1, IL-6, and TNF-a. These results dem- onstrated that LGB significantly inhibited irradiation- induced pulmonary fibrosis. Furthermore, the results suggested promising clinical effect of LGB therapies for treating irradiation-induced pulmonary fibrosis." @default.
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- W3141654055 date "2015-01-01" @default.
- W3141654055 modified "2023-09-27" @default.
- W3141654055 title "Effects of Lettuce Glycoside B in Ameliorating Pulmonary Fibrosis Induced by Irradiation Exposure and its Anti-Oxidative Stress Mechanism" @default.
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