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- W3141681774 abstract "ZNF580 is a novel C2H2 zinc-finger nuclear transcription factor with potential involvement in the transforming growth factor-b1 (TGF-b1) signal transduc- tion pathway. Emerging evidence suggests that TGF-b1 can regulate endothelial nitric oxide synthase (eNOS) expression in endothelial cells. This study aimed to deter- mine if ZNF580 mediated eNOS expression and partici- pated in endothelial cell migration and proliferation via the TGF-b1/Smad2/ZNF580/eNOS signaling pathway. Over- expression/downexpression of ZNF580 in EAhy926 cells leads to the enhancement/decrease of eNOS expression. TGF-b1 downregulated both ZNF580 and eNOS at the mRNA and protein levels in concentration- and time- dependent manners. ZNF580 and eNOS downregulation induced by TGF-b1 was blocked by the specific TGF-b1 type I receptor ALK5 inhibitor, SB431542. Overexpression of ZNF580 attenuated TGF-b1-induced inhibition of EAhy926 cell growth and mobility, and vice versa. These results suggest that ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF- b1/ALK5/Smad2 pathway, and thus plays a crucial role in vascular endothelial cells." @default.
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- W3141681774 date "2014-01-01" @default.
- W3141681774 modified "2023-09-23" @default.
- W3141681774 title "ZNF580 mediates eNOS expression and endothelial cell migration/ proliferation via the TGF-b1/ALK5/Smad2 pathway" @default.
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