Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141708258> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3141708258 abstract "Herpes Simplex Virus 1 (HSV1) is capable of inducing two forms of infection in individuals, and the establishment of which type of infection occurs is linked to the transcriptional activation of viral α genes. One of the HSV1 α genes, ICP22, is known to have multiple functions during virus replication, but its distinct roles are still unclear. This study showed that ICP22 functions as a general repressor for certain viral and cellular promoters, and this transcriptional repression by ICP22 is independent of the specific upstream promoter element, as shown using the CAT enzyme assay system. Further work also found that VP16 interfered with ICP22 mediated transcriptional repression of the viral α4 gene, through interactions with specific elements upstream of the α4 gene promoter. These findings support the possibility that ICP22 and VP16 control transcription of HSV1α genes in a common pathway for the establishment of either viral lytic or latent infections." @default.
- W3141708258 created "2021-04-13" @default.
- W3141708258 creator A5058491122 @default.
- W3141708258 date "2009-01-01" @default.
- W3141708258 modified "2023-09-23" @default.
- W3141708258 title "Transcriptional regulation of the Herpes Simplex Virus 1α-gene by the viral immediate-early protein ICP22 in association with VP16" @default.
- W3141708258 hasPublicationYear "2009" @default.
- W3141708258 type Work @default.
- W3141708258 sameAs 3141708258 @default.
- W3141708258 citedByCount "0" @default.
- W3141708258 crossrefType "journal-article" @default.
- W3141708258 hasAuthorship W3141708258A5058491122 @default.
- W3141708258 hasConcept C101762097 @default.
- W3141708258 hasConcept C104317684 @default.
- W3141708258 hasConcept C138885662 @default.
- W3141708258 hasConcept C140704245 @default.
- W3141708258 hasConcept C150194340 @default.
- W3141708258 hasConcept C153911025 @default.
- W3141708258 hasConcept C158448853 @default.
- W3141708258 hasConcept C159047783 @default.
- W3141708258 hasConcept C165864922 @default.
- W3141708258 hasConcept C179926584 @default.
- W3141708258 hasConcept C182615771 @default.
- W3141708258 hasConcept C186310378 @default.
- W3141708258 hasConcept C2522874641 @default.
- W3141708258 hasConcept C27153228 @default.
- W3141708258 hasConcept C2781196997 @default.
- W3141708258 hasConcept C41895202 @default.
- W3141708258 hasConcept C54355233 @default.
- W3141708258 hasConcept C86803240 @default.
- W3141708258 hasConceptScore W3141708258C101762097 @default.
- W3141708258 hasConceptScore W3141708258C104317684 @default.
- W3141708258 hasConceptScore W3141708258C138885662 @default.
- W3141708258 hasConceptScore W3141708258C140704245 @default.
- W3141708258 hasConceptScore W3141708258C150194340 @default.
- W3141708258 hasConceptScore W3141708258C153911025 @default.
- W3141708258 hasConceptScore W3141708258C158448853 @default.
- W3141708258 hasConceptScore W3141708258C159047783 @default.
- W3141708258 hasConceptScore W3141708258C165864922 @default.
- W3141708258 hasConceptScore W3141708258C179926584 @default.
- W3141708258 hasConceptScore W3141708258C182615771 @default.
- W3141708258 hasConceptScore W3141708258C186310378 @default.
- W3141708258 hasConceptScore W3141708258C2522874641 @default.
- W3141708258 hasConceptScore W3141708258C27153228 @default.
- W3141708258 hasConceptScore W3141708258C2781196997 @default.
- W3141708258 hasConceptScore W3141708258C41895202 @default.
- W3141708258 hasConceptScore W3141708258C54355233 @default.
- W3141708258 hasConceptScore W3141708258C86803240 @default.
- W3141708258 hasLocation W31417082581 @default.
- W3141708258 hasOpenAccess W3141708258 @default.
- W3141708258 hasPrimaryLocation W31417082581 @default.
- W3141708258 hasRelatedWork W1577671916 @default.
- W3141708258 hasRelatedWork W1587678701 @default.
- W3141708258 hasRelatedWork W1966435564 @default.
- W3141708258 hasRelatedWork W1996987329 @default.
- W3141708258 hasRelatedWork W1999312866 @default.
- W3141708258 hasRelatedWork W2003090419 @default.
- W3141708258 hasRelatedWork W2020354238 @default.
- W3141708258 hasRelatedWork W2034604948 @default.
- W3141708258 hasRelatedWork W2046261180 @default.
- W3141708258 hasRelatedWork W2057328575 @default.
- W3141708258 hasRelatedWork W2101840360 @default.
- W3141708258 hasRelatedWork W2117627665 @default.
- W3141708258 hasRelatedWork W2124709747 @default.
- W3141708258 hasRelatedWork W2125964404 @default.
- W3141708258 hasRelatedWork W2139086665 @default.
- W3141708258 hasRelatedWork W2139843368 @default.
- W3141708258 hasRelatedWork W2140725855 @default.
- W3141708258 hasRelatedWork W2141866279 @default.
- W3141708258 hasRelatedWork W2395750117 @default.
- W3141708258 hasRelatedWork W3152788002 @default.
- W3141708258 isParatext "false" @default.
- W3141708258 isRetracted "false" @default.
- W3141708258 magId "3141708258" @default.
- W3141708258 workType "article" @default.