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- W3141736385 endingPage "1700" @default.
- W3141736385 startingPage "1700" @default.
- W3141736385 abstract "Uveal melanoma (UM) is currently classified by the World Health Organisation as a melanoma caused by risk factors other than cumulative solar damage. However, factors relating to ultraviolet radiation (UVR) susceptibility such as light-coloured skin and eyes, propensity to burn, and proximity to the equator, frequently correlate with higher risk of UM. These risk factors echo those of the far more common cutaneous melanoma (CM), which is widely accepted to be caused by excessive UVR exposure, suggesting a role of UVR in the development and progression of a proportion of UM. Indeed, this could mean that countries, such as Australia, with high UVR exposure and the highest incidences of CM would represent a similarly high incidence of UM if UVR exposure is truly involved. Most cases of UM lack the typical genetic mutations that are related to UVR damage, although recent evidence in a small minority of cases has shown otherwise. This review therefore reassesses statistical, environmental, anatomical, and physiological evidence for and against the role of UVR in the aetiology of UM." @default.
- W3141736385 created "2021-04-13" @default.
- W3141736385 creator A5005203967 @default.
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- W3141736385 creator A5048307488 @default.
- W3141736385 creator A5076911708 @default.
- W3141736385 date "2021-04-03" @default.
- W3141736385 modified "2023-09-30" @default.
- W3141736385 title "The Impact of Ultraviolet Radiation on the Aetiology and Development of Uveal Melanoma" @default.
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