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- W3141750356 abstract "Objective To investigate the activation of transcription factors and induction of cytokines from alveolar macrophages in chronic obstructive pulmonary disease (COPD). Methods Alveolar macrophages were collected by fibrobronchoscopy from 8 patients with chronic bronchitis, 8 patients with COPD, and 8 healthy volunteers. All patients were at stable stage. The macrophages thus collected were cultured and stimulated with lipopolysaccharide (LPS, 10 μg/ml). The IL-8, IL-1β , TNFα and IL-6 thus produced were measured by ELISA in the supernatant. Nuclear factor-κB (NFκB), activator protein-1 (AP-1), AP-2 and AP-3 were detected by electrophoretic mobility shift assay. Results The concentration of IL-8 released from macrophages of patients with COPD at stable stage before LPS stimulation was about 3 times higher than that in the healthy control (F=4.34,P0.05). The concentration of IL-8 released from macrophages in patients with COPD was increased further after LPS stimulation in comparison to that in healthy controls(F=3.56,P0.05). The concentration of IL-1β and that of TNFα released from macrophages of COPD patients were further increased after LPS stimulation (P0.05) in the COPD patients, but there was no difference in the concentration of IL-1β and between the control and COPD patients before LPS stimulation. The constitutive activity of AP-1 and the activity of NFκB induced by LPS were higher in the patients with COPD than in the controls. Conclusion The alverlar macrophages of patients with COPD at stable stage may release higher concentration of IL-8 and IL-1β . LPS stimulation incerases the release of IL-1β and TNFα of alveolar macrophages. Enhancement of activity of NFκB and AP-1 may positively regulate the production of IL-8 and IL-1β in the airflow obstruction." @default.
- W3141750356 created "2021-04-13" @default.
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- W3141750356 date "2001-01-01" @default.
- W3141750356 modified "2023-09-26" @default.
- W3141750356 title "Activation of transcription factors and induction of cytokines from macrophages in chronic obstructive pulmonary disease" @default.
- W3141750356 hasPublicationYear "2001" @default.
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