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- W3141750647 abstract "Helicobacter pylori(H.pylori)infection is one of the most common infections in human beings worldwide.H.pylori express lipopolysaccharides and flagellin that do not activate efficiently Toll-like receptors and express dedicated effectors,such asγ-glutamyl transpeptidase,vacuolating cytotoxin(vacA),arginase,that actively induce tolerogenic signals.In this perspective,H.pylori can be considered as a commensal bacteria belonging to the stomach microbiota.However,when present in the stomach,H.pylori reduce the overall diversity of the gastric microbiota and promote gastric inflammation by inducing Nod1-dependent pro-inflammatory program and by activating neutrophils through the production of a neutrophil activating protein.The maintenance of a chronic inflammation in the gastric mucosa and the direct action of virulence factors(vacA and cytotoxinassociated gene A)confer pro-carcinogenic activities to H.pylori.Hence,H.pylori cannot be considered as symbiotic bacteria but rather as part of the pathobiont.The development of a H.pylori vaccine will bring health benefits for individuals infected with antibiotic resistant H.pylori strains and population of underdeveloped countries." @default.
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- W3141750647 date "2014-01-01" @default.
- W3141750647 modified "2023-09-24" @default.
- W3141750647 title "Immune responses to Helicobacter pylori infection" @default.
- W3141750647 hasPublicationYear "2014" @default.
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