FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141754995> ?p ?o ?g. }

• W3141754995 endingPage "S341" @default.
• W3141754995 startingPage "S337" @default.
• W3141754995 abstract "Diabetes induces a high degree of morbidity and significant reduction of life expectancy in affected subjects. Microvascular complications include retinopathy, nephropathy, and neuropathy, which frequently are underlying factors of major morbidity and disability associated with diabetes. However, macrovascular complications, and mainly cardiovascular disease, are still the leading causes of death in diabetic subjects. Thus, improved cardiovascular outcome will have a clearly favorable effect on mortality in this group of patients.Since the introduction of the U.K. Prospective Diabetes Study (UKPDS) trials in 1998, it has become widely accepted that controlling hyperglycemia improves microvascular outcome in diabetic patients (1,2). However, to date, there is no compelling evidence that improving glycemic control has, in itself, beneficial effects on macrovascular complications and cardiovascular clinical end points.Although hyperglycemia is the hallmark of diabetes, it is still unclear whether there is a causative relationship between increased blood glucose levels and the evolution of arterial atherosclerosis. Moreover, other metabolic disorders that have been clearly linked to plaque formation seem to coexist with, rather than being caused by, hyperglycemia. These metabolic abnormalities include dyslipidemia, abdominal obesity, hypertension, low-grade inflammation, and coagulopathies. This hypothesis is supported by the findings of Haffner et al. (3) from a population-based study of diabetes and cardiovascular disease. In this study, it was demonstrated that normoglycemic subjects who subsequently developed diabetes had an atherogenic pattern of risk factors, including dyslipidemia, overweight, insulin resistance, and hypertension, years before frank diabetes was diagnosed (3). In another study, Haffner et al. (4) clearly demonstrated that diabetic patients without previous myocardial infarction (MI) have as high a risk of MI as nondiabetic patients with previous MI. Overall, these findings support the hypothesis that diabetes and other atherogenic risk factors are manifestations of one entity leading to arterial atherosclerosis. The constellation of insulin resistance and …" @default.
• W3141754995 created "2021-04-13" @default.
• W3141754995 creator A5053301514 @default.
• W3141754995 creator A5073517018 @default.
• W3141754995 date "2009-11-01" @default.
• W3141754995 modified "2023-09-27" @default.
• W3141754995 title "Is There Evidence That Oral Hypoglycemic Agents Reduce Cardiovascular Morbidity or Mortality? No" @default.
• W3141754995 cites W172609984 @default.
• W3141754995 cites W1891884419 @default.
• W3141754995 cites W1968973887 @default.
• W3141754995 cites W1969157512 @default.
• W3141754995 cites W1977188464 @default.
• W3141754995 cites W1977390060 @default.
• W3141754995 cites W1987941106 @default.
• W3141754995 cites W1997402595 @default.
• W3141754995 cites W1997416444 @default.
• W3141754995 cites W2017421207 @default.
• W3141754995 cites W2035838062 @default.
• W3141754995 cites W2046113689 @default.
• W3141754995 cites W2058331351 @default.
• W3141754995 cites W2069842490 @default.
• W3141754995 cites W2086393043 @default.
• W3141754995 cites W2090414284 @default.
• W3141754995 cites W2094662494 @default.
• W3141754995 cites W2102319947 @default.
• W3141754995 cites W2102675827 @default.
• W3141754995 cites W2114670258 @default.
• W3141754995 cites W2120774442 @default.
• W3141754995 cites W2123403285 @default.
• W3141754995 cites W2127125241 @default.
• W3141754995 cites W2131215476 @default.
• W3141754995 cites W2140678750 @default.
• W3141754995 cites W2154307369 @default.
• W3141754995 cites W2159969745 @default.
• W3141754995 cites W2161310510 @default.
• W3141754995 cites W2165247092 @default.
• W3141754995 cites W2170271198 @default.
• W3141754995 cites W2188846692 @default.
• W3141754995 cites W2331274940 @default.
• W3141754995 cites W2337454357 @default.
• W3141754995 cites W4236865877 @default.
• W3141754995 cites W4297681290 @default.
• W3141754995 doi "https://doi.org/10.2337/dc09-s335" @default.
• W3141754995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2811474" @default.
• W3141754995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19875577" @default.
• W3141754995 hasPublicationYear "2009" @default.
• W3141754995 type Work @default.
• W3141754995 sameAs 3141754995 @default.
• W3141754995 citedByCount "17" @default.
• W3141754995 countsByYear W31417549952014 @default.
• W3141754995 countsByYear W31417549952015 @default.
• W3141754995 countsByYear W31417549952016 @default.
• W3141754995 countsByYear W31417549952018 @default.
• W3141754995 countsByYear W31417549952020 @default.
• W3141754995 countsByYear W31417549952023 @default.
• W3141754995 crossrefType "journal-article" @default.
• W3141754995 hasAuthorship W3141754995A5053301514 @default.
• W3141754995 hasAuthorship W3141754995A5073517018 @default.
• W3141754995 hasBestOaLocation W31417549951 @default.
• W3141754995 hasConcept C126322002 @default.
• W3141754995 hasConcept C134018914 @default.
• W3141754995 hasConcept C17744445 @default.
• W3141754995 hasConcept C177713679 @default.
• W3141754995 hasConcept C194828623 @default.
• W3141754995 hasConcept C199539241 @default.
• W3141754995 hasConcept C2777180221 @default.
• W3141754995 hasConcept C2779473830 @default.
• W3141754995 hasConcept C2910525902 @default.
• W3141754995 hasConcept C555293320 @default.
• W3141754995 hasConcept C71924100 @default.
• W3141754995 hasConceptScore W3141754995C126322002 @default.
• W3141754995 hasConceptScore W3141754995C134018914 @default.
• W3141754995 hasConceptScore W3141754995C17744445 @default.
• W3141754995 hasConceptScore W3141754995C177713679 @default.
• W3141754995 hasConceptScore W3141754995C194828623 @default.
• W3141754995 hasConceptScore W3141754995C199539241 @default.
• W3141754995 hasConceptScore W3141754995C2777180221 @default.
• W3141754995 hasConceptScore W3141754995C2779473830 @default.
• W3141754995 hasConceptScore W3141754995C2910525902 @default.
• W3141754995 hasConceptScore W3141754995C555293320 @default.
• W3141754995 hasConceptScore W3141754995C71924100 @default.
• W3141754995 hasIssue "suppl_2" @default.
• W3141754995 hasLocation W31417549951 @default.
• W3141754995 hasLocation W31417549952 @default.
• W3141754995 hasLocation W31417549953 @default.
• W3141754995 hasLocation W31417549954 @default.
• W3141754995 hasOpenAccess W3141754995 @default.
• W3141754995 hasPrimaryLocation W31417549951 @default.
• W3141754995 hasRelatedWork W1563850031 @default.
• W3141754995 hasRelatedWork W2025193597 @default.
• W3141754995 hasRelatedWork W2027089505 @default.
• W3141754995 hasRelatedWork W2042489430 @default.
• W3141754995 hasRelatedWork W2045367862 @default.
• W3141754995 hasRelatedWork W2074686124 @default.
• W3141754995 hasRelatedWork W2083479052 @default.
• W3141754995 hasRelatedWork W2115778339 @default.
• W3141754995 hasRelatedWork W2415759662 @default.
• W3141754995 hasRelatedWork W3036934084 @default.

• next