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- W3141805009 abstract "[Objective] To investigate the relationship of human parvovirus B19 infection between Rheumatoid Arthritis and the role of immune response. [Methods] 56 patients with RA and 55 unrelated controls (51 trauma and 4 osteoarthritis) were enrolled. Anti-parvovirus B19 VP2 IgM (B19-V2-IgM) antibodies were detected in sera of patients with RA and controls by the enzyme immunoassay method. B19 DNA was measured in the sera and synovia of above patients and in bone marrow with RA and controls by polymerase chain reaction (PCR). [Results] The prevalence of B19 infection was significantly increased in patients with RA compared with controls. The positive rate (33.9%) of B19-DNA in sera was significantly higher in RA patients than that in controls (5.5%). The positive rate (35.7%) of B19-DNA in synovia was significantly higher in RA patients than that in controls (0%). 14 (25.0%) of the 56 RA patients and 2 (3.6%) of the control group showed positive for B19- VP2-IgM (P﹤0.01). In 56 RA patients, 12 were positive for both B19-DNA and B19-VP2-IgM, while 7 were only positive for B19-DNA and 2 B19-VP2-IgM, and 35 were negative for both B19-DNA and B19-VP2-IgM. Crude agreement between the detecting results of B19-DNA and B19-VP2-IgM was 83.9%, and they were significantly consistent (P﹥0.05). The positive rate (51.6%) of B19-DNA in bone marrow was significantly higher in RA patients than that in controls too. Interleukin (IL) -1beta, IL-5, IL-6, IL-8, IL-10, tumour necrosis factor (TNF) -alpha were significantly higher in patients with RA compared with control groups (P﹤0.01). [Conclusion] The prevalence of B19 infection was significantly higher in patients with RA than in controls. B19 infection may play a role in susceptibility to RA." @default.
- W3141805009 created "2021-04-13" @default.
- W3141805009 creator A5054967280 @default.
- W3141805009 date "2010-01-01" @default.
- W3141805009 modified "2023-09-25" @default.
- W3141805009 title "THE RELATIONSHIP OF HUMAN PARVOVIRUS B19 INFECTION WITH OCCURRENCE OF RHEUMATOID ARTHRITIS" @default.
- W3141805009 hasPublicationYear "2010" @default.
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