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- W3141891867 abstract "The improvement of the survival rates of var- ious cancer patients has resulted in increased focus on the long-term complications of treatment. Most anticancer chemotherapeutic agents are gonadotoxic, and sterility is therefore one of the most common complications for can- cer survivors. The degree of gonadal dysfunction induced by anticancer chemotherapeutic agents seems to be drug specific and dose related. Following the development of new chemotherapeutic agents that have high benefit-to-risk ratios, sufficient sperm can be acquired by collection of ejaculated semen after the treatment in relatively many cases, and assisted reproductive techniques enable con- ceptions with even severe spermatogenesis dysfunction. However, anticancer chemotherapeutic agents have con- sistently exhibited the potential to induce permanent azo- ospermia. Cryopreservation of semen, which is currently the only proven successful option for future fertility pres- ervation in male cancer patients, should certainly be rec- ommended before cancer therapy. However, to date, no established effective methods have shown the capability to protect gonadal function from anticancer treatment in prepubertal cancer patients." @default.
- W3141891867 created "2021-04-13" @default.
- W3141891867 creator A5073731258 @default.
- W3141891867 date "2011-01-01" @default.
- W3141891867 modified "2023-09-27" @default.
- W3141891867 title "Anticancer chemotherapeutic agents and testicular dysfunction" @default.
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