Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141930834> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3141930834 endingPage "5016" @default.
- W3141930834 startingPage "5008" @default.
- W3141930834 abstract "AIM:To investigate the association between mutations in oligomerisation domain 2/caspase recruitment domains 15(NOD2/CARD15)and the natural history of Crohn’s disease(CD)to identify patients who would benefit from early aggressive medical intervention.METHODS:We recruited thirty consecutive unrelated CD patients with a history of ileo-caecal or small bowel resection during the period 1980-2000;Fifteen patients of these had post-operative relapse that required further surgery and fifteen did not.Full sequencing of the NOD2/CARD15 gene using dHPLC for exons 3,5,7,10 and 12 and direct sequencing for exons 2,4,6,8,9 and 11 was conducted.CD patients categorized as carrying variants were anyone with at least 1 variant of the NOD2/CARD15 gene.RESULTS:About 13.3%of the cohort(four patients)carried at least one mutant allele of 3020ins C of the NOD2/CARD15 gene.There were 20 males and 10females with a mean age of 43.3 years(range 25-69years).The mean follow up was 199.6 mo and a median of 189.5 mo.Sixteen sequence variations within the NOD2/CARD15 gene were identified,with 9 of them occurring with an allele frequency of greater than 10%.In this study,there was a trend to suggest that patients with the 3020ins C mutation have a higher frequency of operations compared to those without the mutation.Patients with the 3020insC mutation had a significantly shorter time between the diagnosis of CD and initial surgery.This study included Australian patients of ethnically heterogenous background unlike previous studies conducted in different countries.CONCLUSION:These findings suggest that patients carrying NOD2/CARD15 mutations follow a rapid and more aggressive form of Crohn’s disease showing a trend for multiple surgical interventions and significantly shorter time to early surgery." @default.
- W3141930834 created "2021-04-13" @default.
- W3141930834 creator A5008871376 @default.
- W3141930834 creator A5010744942 @default.
- W3141930834 creator A5027053221 @default.
- W3141930834 creator A5029222495 @default.
- W3141930834 creator A5032609941 @default.
- W3141930834 creator A5039139994 @default.
- W3141930834 creator A5055353034 @default.
- W3141930834 creator A5065813940 @default.
- W3141930834 creator A5066341191 @default.
- W3141930834 creator A5066364505 @default.
- W3141930834 date "2014-01-01" @default.
- W3141930834 modified "2023-09-23" @default.
- W3141930834 title "Prediction of Crohn’s disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort" @default.
- W3141930834 hasPublicationYear "2014" @default.
- W3141930834 type Work @default.
- W3141930834 sameAs 3141930834 @default.
- W3141930834 citedByCount "0" @default.
- W3141930834 crossrefType "journal-article" @default.
- W3141930834 hasAuthorship W3141930834A5008871376 @default.
- W3141930834 hasAuthorship W3141930834A5010744942 @default.
- W3141930834 hasAuthorship W3141930834A5027053221 @default.
- W3141930834 hasAuthorship W3141930834A5029222495 @default.
- W3141930834 hasAuthorship W3141930834A5032609941 @default.
- W3141930834 hasAuthorship W3141930834A5039139994 @default.
- W3141930834 hasAuthorship W3141930834A5055353034 @default.
- W3141930834 hasAuthorship W3141930834A5065813940 @default.
- W3141930834 hasAuthorship W3141930834A5066341191 @default.
- W3141930834 hasAuthorship W3141930834A5066364505 @default.
- W3141930834 hasConcept C104317684 @default.
- W3141930834 hasConcept C126322002 @default.
- W3141930834 hasConcept C180754005 @default.
- W3141930834 hasConcept C2776053618 @default.
- W3141930834 hasConcept C2779134260 @default.
- W3141930834 hasConcept C2779280984 @default.
- W3141930834 hasConcept C36823959 @default.
- W3141930834 hasConcept C37463918 @default.
- W3141930834 hasConcept C501734568 @default.
- W3141930834 hasConcept C54355233 @default.
- W3141930834 hasConcept C71924100 @default.
- W3141930834 hasConcept C72563966 @default.
- W3141930834 hasConcept C7573103 @default.
- W3141930834 hasConcept C86803240 @default.
- W3141930834 hasConcept C90924648 @default.
- W3141930834 hasConceptScore W3141930834C104317684 @default.
- W3141930834 hasConceptScore W3141930834C126322002 @default.
- W3141930834 hasConceptScore W3141930834C180754005 @default.
- W3141930834 hasConceptScore W3141930834C2776053618 @default.
- W3141930834 hasConceptScore W3141930834C2779134260 @default.
- W3141930834 hasConceptScore W3141930834C2779280984 @default.
- W3141930834 hasConceptScore W3141930834C36823959 @default.
- W3141930834 hasConceptScore W3141930834C37463918 @default.
- W3141930834 hasConceptScore W3141930834C501734568 @default.
- W3141930834 hasConceptScore W3141930834C54355233 @default.
- W3141930834 hasConceptScore W3141930834C71924100 @default.
- W3141930834 hasConceptScore W3141930834C72563966 @default.
- W3141930834 hasConceptScore W3141930834C7573103 @default.
- W3141930834 hasConceptScore W3141930834C86803240 @default.
- W3141930834 hasConceptScore W3141930834C90924648 @default.
- W3141930834 hasIssue "17" @default.
- W3141930834 hasLocation W31419308341 @default.
- W3141930834 hasOpenAccess W3141930834 @default.
- W3141930834 hasPrimaryLocation W31419308341 @default.
- W3141930834 hasRelatedWork W167821824 @default.
- W3141930834 hasRelatedWork W1874197329 @default.
- W3141930834 hasRelatedWork W2059569464 @default.
- W3141930834 hasRelatedWork W2064027072 @default.
- W3141930834 hasRelatedWork W2066961404 @default.
- W3141930834 hasRelatedWork W2071366086 @default.
- W3141930834 hasRelatedWork W2100759119 @default.
- W3141930834 hasRelatedWork W2100760934 @default.
- W3141930834 hasRelatedWork W2107179569 @default.
- W3141930834 hasRelatedWork W2124892707 @default.
- W3141930834 hasRelatedWork W2240279061 @default.
- W3141930834 hasRelatedWork W2366166987 @default.
- W3141930834 hasRelatedWork W2388119112 @default.
- W3141930834 hasRelatedWork W2389399974 @default.
- W3141930834 hasRelatedWork W2397945264 @default.
- W3141930834 hasRelatedWork W2413068014 @default.
- W3141930834 hasRelatedWork W2785125869 @default.
- W3141930834 hasRelatedWork W3046191725 @default.
- W3141930834 hasRelatedWork W3048984907 @default.
- W3141930834 hasRelatedWork W2741702843 @default.
- W3141930834 isParatext "false" @default.
- W3141930834 isRetracted "false" @default.
- W3141930834 magId "3141930834" @default.
- W3141930834 workType "article" @default.