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- W3141972025 abstract "背景肿瘤坏死因素α(TNF α) 是在煽动性的肠疾病(IBD ) 的致病被含有的重要 proinflammatorycytokine。Recentstudies 在 IBD 评估了 TNF 倡导者多型性的角色，而数据是不一致的。在不同却同质的人口可以帮助澄清这些协会的人种上的 Trans 种族的印射。我们在中国汉种族人口调查在 TNF 倡导者多型性和危险性之间的协会到 ulcerative 大肠炎(UC ) 。方法我们 studied110 从浙江省的无关的 UC 病人和 292 健康控制，中国。为 6common TNF 倡导者多型性的 Genotyping (TNF -1031T/C,-863C/A,-857C/T,-380G/A,-308G/A,-238G/A) 被聚合酶链反应执行顺序特定的教材(PCR-SSP ) 。结果 TNF-308A 与疾病被联系(等位基因频率病人 14.6% 对控制 8.9% ， P=0.02 ) 。TNF -857T 在病人，但是没有统计意义被增加(等位基因频率 17.3% 对 12.2% ， P=0.06 ) 。Haplotype 分析揭示了包括二的 6 haplotypes (H5 和 H3 ) ，它包含了 TNF-308A。H5 与疾病被联系(haplotype 频率病人 -12.3% 对控制 7.5% ， P=0.03 ) 。笔记，稀罕 haplotype H3 以前没在白种人 populations.Homozygosity 被识别因为在每 TNF promotersingle 核苷酸多型性(SNP ) 包括普通等位基因的 haplotype H4 否定地与疾病被联系(病人对 controls24.5% 对 34.9% ， P < 0.05 ) 。我们与 ulcerative 大肠炎在中国病人与 TNF -308A 多型性报导协会的结论。在中国汉种族人口的功能的学习现在被要求。" @default.
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- W3141972025 date "2006-01-01" @default.
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- W3141972025 title "Genetic susceptibility to ulcerative colitis in the Chinese Han ethnic population： association with TNF polymorphisms" @default.
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