Matches in SemOpenAlex for { <https://semopenalex.org/work/W314197816> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W314197816 endingPage "147.1" @default.
- W314197816 startingPage "147.1" @default.
- W314197816 abstract "Abstract In a recent report, we demonstrated that IL-4 inhibits prostaglandins (PGs) production in follicular dendritic cell (FDC)-like cells, HK. To understand the inhibitory mechanisms of IL-4, its effects on the biosynthesis of enzymes in charge of PG production were assessed in this study. Although IL-4 did not affect COX-1 expression, it specifically inhibited LPS-induced COX-2 biosynthesis at the mRNA and protein levels. Protein expression of mPGES-1, a downstream enzyme of COX-2, was also markedly diminished by IL-4 but not by IL-10, maximizing the inhibitory activity. Next, we attempted to identify the early signaling molecules that led to this inhibition of COX-2 expression. Although IL-4 induced tyrosine phosphorylation of JAK1 and TYK2, RNA interference experiments revealed that only JAK1 was responsible for the IL-4-stimulated STAT6 phosphorylation. Knocking down JAK1 and STAT6 ablated the inhibitory effect of IL-4 on COX-2 expression and significantly reduced production of PGE2 and prostacyclin. These results stress the essential roles of JAK1 and STAT6 in the early signaling pathway of IL-4 leading to suppression of COX-2 expression and repression of PG production by HK cells. Our results suggest that T cells via IL-4 play a regulatory role in PG generation in FDC. IL-4 therapeutics may be applied to immune disorders where normal and ectopic expression of germinal center reactions needs to be regulated." @default.
- W314197816 created "2016-06-24" @default.
- W314197816 creator A5045363639 @default.
- W314197816 creator A5077659343 @default.
- W314197816 date "2011-04-01" @default.
- W314197816 modified "2023-09-25" @default.
- W314197816 title "IL-4 suppresses prostaglandins production in human follicular dendritic cells by repressing COX-2 through JAK1-STAT6 (147.1)" @default.
- W314197816 doi "https://doi.org/10.4049/jimmunol.186.supp.147.1" @default.
- W314197816 hasPublicationYear "2011" @default.
- W314197816 type Work @default.
- W314197816 sameAs 314197816 @default.
- W314197816 citedByCount "0" @default.
- W314197816 crossrefType "journal-article" @default.
- W314197816 hasAuthorship W314197816A5045363639 @default.
- W314197816 hasAuthorship W314197816A5077659343 @default.
- W314197816 hasConcept C104317684 @default.
- W314197816 hasConcept C11960822 @default.
- W314197816 hasConcept C145430368 @default.
- W314197816 hasConcept C185592680 @default.
- W314197816 hasConcept C191732599 @default.
- W314197816 hasConcept C203014093 @default.
- W314197816 hasConcept C2777553839 @default.
- W314197816 hasConcept C55493867 @default.
- W314197816 hasConcept C62478195 @default.
- W314197816 hasConcept C86803240 @default.
- W314197816 hasConcept C8891405 @default.
- W314197816 hasConcept C95444343 @default.
- W314197816 hasConcept C97037327 @default.
- W314197816 hasConceptScore W314197816C104317684 @default.
- W314197816 hasConceptScore W314197816C11960822 @default.
- W314197816 hasConceptScore W314197816C145430368 @default.
- W314197816 hasConceptScore W314197816C185592680 @default.
- W314197816 hasConceptScore W314197816C191732599 @default.
- W314197816 hasConceptScore W314197816C203014093 @default.
- W314197816 hasConceptScore W314197816C2777553839 @default.
- W314197816 hasConceptScore W314197816C55493867 @default.
- W314197816 hasConceptScore W314197816C62478195 @default.
- W314197816 hasConceptScore W314197816C86803240 @default.
- W314197816 hasConceptScore W314197816C8891405 @default.
- W314197816 hasConceptScore W314197816C95444343 @default.
- W314197816 hasConceptScore W314197816C97037327 @default.
- W314197816 hasIssue "1_Supplement" @default.
- W314197816 hasLocation W3141978161 @default.
- W314197816 hasOpenAccess W314197816 @default.
- W314197816 hasPrimaryLocation W3141978161 @default.
- W314197816 hasRelatedWork W1531825933 @default.
- W314197816 hasRelatedWork W1965702849 @default.
- W314197816 hasRelatedWork W1975999653 @default.
- W314197816 hasRelatedWork W2020365526 @default.
- W314197816 hasRelatedWork W2032718602 @default.
- W314197816 hasRelatedWork W2094732767 @default.
- W314197816 hasRelatedWork W2110117043 @default.
- W314197816 hasRelatedWork W2530220159 @default.
- W314197816 hasRelatedWork W2571485264 @default.
- W314197816 hasRelatedWork W4213392954 @default.
- W314197816 hasVolume "186" @default.
- W314197816 isParatext "false" @default.
- W314197816 isRetracted "false" @default.
- W314197816 magId "314197816" @default.
- W314197816 workType "article" @default.