Matches in SemOpenAlex for { <https://semopenalex.org/work/W3141987310> ?p ?o ?g. }
- W3141987310 endingPage "3464" @default.
- W3141987310 startingPage "3464" @default.
- W3141987310 abstract "The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian, colorectal, prostate, glioblastoma and endometrial cancers. PI3K signaling plays an important role in cancer cell survival, angiogenesis and metastasis, making it a promising therapeutic target. There are several ongoing and completed clinical trials involving PI3K inhibitors (pan, isoform-specific and dual PI3K/mTOR) with the goal to find efficient PI3K inhibitors that could overcome resistance to current therapies. This review focuses on the current landscape of various PI3K inhibitors either as monotherapy or in combination therapies and the treatment outcomes involved in various phases of clinical trials in different cancer types. There is a discussion of the drug-related toxicities, challenges associated with these PI3K inhibitors and the adverse events leading to treatment failure. In addition, novel PI3K drugs that have potential to be translated in the clinic are highlighted." @default.
- W3141987310 created "2021-04-13" @default.
- W3141987310 creator A5003656271 @default.
- W3141987310 creator A5013543293 @default.
- W3141987310 creator A5021590694 @default.
- W3141987310 creator A5024504957 @default.
- W3141987310 creator A5069099119 @default.
- W3141987310 date "2021-03-27" @default.
- W3141987310 modified "2023-10-14" @default.
- W3141987310 title "PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects" @default.
- W3141987310 cites W1515841604 @default.
- W3141987310 cites W1553539229 @default.
- W3141987310 cites W1886775400 @default.
- W3141987310 cites W1929743028 @default.
- W3141987310 cites W1956543993 @default.
- W3141987310 cites W1967187359 @default.
- W3141987310 cites W1968852924 @default.
- W3141987310 cites W1969762630 @default.
- W3141987310 cites W1971843650 @default.
- W3141987310 cites W1973781319 @default.
- W3141987310 cites W1975570973 @default.
- W3141987310 cites W1975685376 @default.
- W3141987310 cites W1979937839 @default.
- W3141987310 cites W1982401280 @default.
- W3141987310 cites W1985789209 @default.
- W3141987310 cites W1987642183 @default.
- W3141987310 cites W1988878042 @default.
- W3141987310 cites W1992477322 @default.
- W3141987310 cites W1992643899 @default.
- W3141987310 cites W1995618664 @default.
- W3141987310 cites W1997640760 @default.
- W3141987310 cites W1997870023 @default.
- W3141987310 cites W1999065747 @default.
- W3141987310 cites W2000954296 @default.
- W3141987310 cites W2001430754 @default.
- W3141987310 cites W2001999652 @default.
- W3141987310 cites W2010601523 @default.
- W3141987310 cites W2014620054 @default.
- W3141987310 cites W2018343427 @default.
- W3141987310 cites W2023041438 @default.
- W3141987310 cites W2024441913 @default.
- W3141987310 cites W2024933597 @default.
- W3141987310 cites W2025188980 @default.
- W3141987310 cites W2025947919 @default.
- W3141987310 cites W2028549997 @default.
- W3141987310 cites W2029286823 @default.
- W3141987310 cites W2029754521 @default.
- W3141987310 cites W2033182904 @default.
- W3141987310 cites W2039071845 @default.
- W3141987310 cites W2043377688 @default.
- W3141987310 cites W2050105520 @default.
- W3141987310 cites W2054318449 @default.
- W3141987310 cites W2057366353 @default.
- W3141987310 cites W2058579552 @default.
- W3141987310 cites W2059259875 @default.
- W3141987310 cites W2065502412 @default.
- W3141987310 cites W2066564017 @default.
- W3141987310 cites W2070073293 @default.
- W3141987310 cites W2074517075 @default.
- W3141987310 cites W2075828428 @default.
- W3141987310 cites W2080551472 @default.
- W3141987310 cites W2083293423 @default.
- W3141987310 cites W2086281394 @default.
- W3141987310 cites W2088118561 @default.
- W3141987310 cites W2091695507 @default.
- W3141987310 cites W2092982811 @default.
- W3141987310 cites W2094399892 @default.
- W3141987310 cites W2095447519 @default.
- W3141987310 cites W2095592674 @default.
- W3141987310 cites W2099019973 @default.
- W3141987310 cites W2100288916 @default.
- W3141987310 cites W2101885674 @default.
- W3141987310 cites W2101982508 @default.
- W3141987310 cites W2102004296 @default.
- W3141987310 cites W2108541764 @default.
- W3141987310 cites W2113343850 @default.
- W3141987310 cites W2120021279 @default.
- W3141987310 cites W2121039860 @default.
- W3141987310 cites W2121087867 @default.
- W3141987310 cites W2126390772 @default.
- W3141987310 cites W2128855114 @default.
- W3141987310 cites W2129172946 @default.
- W3141987310 cites W2134861285 @default.
- W3141987310 cites W2135627690 @default.
- W3141987310 cites W2137145604 @default.
- W3141987310 cites W2141134269 @default.
- W3141987310 cites W2144040817 @default.
- W3141987310 cites W2149299767 @default.
- W3141987310 cites W2151172909 @default.
- W3141987310 cites W2151258296 @default.
- W3141987310 cites W2153096480 @default.
- W3141987310 cites W2153195684 @default.
- W3141987310 cites W2154871907 @default.
- W3141987310 cites W2155228605 @default.
- W3141987310 cites W2156918228 @default.
- W3141987310 cites W2156928849 @default.
- W3141987310 cites W2165280661 @default.
- W3141987310 cites W2165404212 @default.