Matches in SemOpenAlex for { <https://semopenalex.org/work/W31419984> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W31419984 endingPage "80" @default.
- W31419984 startingPage "872" @default.
- W31419984 abstract "Orthotopic heart transplantation may interrupt key neural and humoral homeostatic mechanisms that normally adjust Na+ and fluid excretion to changes in intake. Such an interruption could lead to plasma volume expansion.We measured plasma volume and fluid regulatory hormones under standardized conditions in 11 heart transplant recipients (58 +/- 7 years old; mean +/- standard deviation) 21 +/- 4 months after transplantation, in 6 liver transplant recipients (51 +/- 6 years old) 13 +/- 8 months after transplantation (cyclosporine control group), and in 7 normal healthy control subjects (61 +/- 9 years old). Administration of all diuretics and antihypertensive drugs was discontinued before the study. After 3 days during which subjects ate a constant diet containing 87 mEq of Na+ per 24 hours, plasma volume was measured by a modified Evans blue dye (T-1824) dilution technique. Renal creatinine clearance was measured and blood samples were drawn for determination of plasma levels of vasopressin, angiotensin II, aldosterone, atrial natriuretic peptide, and plasma renin activity.Supine resting plasma renin activity, angiotensin II, and aldosterone (renin-angiotensin-aldosterone axis) and vasopressin levels were not different among the control, heart transplant, and liver transplant groups. However, there was a trend toward elevated angiotensin II (p < or = 0.08) and aldosterone (p < or = 0.08) levels in the heart transplant recipients. Atrial natriuretic peptide levels were significantly elevated two to threefold in the heart transplant recipients when compared with those in the two control groups. Blood volume, normalized for body weight (milliliters per kilogram), was significantly greater (14%) in the heart transplant recipients when compared with that in liver transplant recipients and normal healthy control subjects. Blood volume values did not differ (p > or = 0.05) between the two control groups.Extracellular fluid volume expansion (+14%) occurs in clinically stable heart transplant recipients who become hypertensive. Although hyperactivity of the renin-angiotensin-aldosterone axis is not apparent during supine resting conditions, our data suggest that the renin-angiotensin-aldosterone system is not responsive to a hypervolemic stimulus and this is likely a consequence of chronic cardiac deafferentation. Thus, poor adaptation of the renin-angiotensin-aldosterone system to fluid retention may be partly responsible for the incidence and severity of posttransplantation hypertension in some heart transplant recipients." @default.
- W31419984 created "2016-06-24" @default.
- W31419984 creator A5005797727 @default.
- W31419984 creator A5010231747 @default.
- W31419984 creator A5028850387 @default.
- W31419984 creator A5032413566 @default.
- W31419984 creator A5032447495 @default.
- W31419984 creator A5049660576 @default.
- W31419984 creator A5063838301 @default.
- W31419984 date "1996-09-01" @default.
- W31419984 modified "2023-09-27" @default.
- W31419984 title "Fluid homeostasis after heart transplantation: the role of cardiac denervation." @default.
- W31419984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8889982" @default.
- W31419984 hasPublicationYear "1996" @default.
- W31419984 type Work @default.
- W31419984 sameAs 31419984 @default.
- W31419984 citedByCount "18" @default.
- W31419984 countsByYear W314199842021 @default.
- W31419984 countsByYear W314199842023 @default.
- W31419984 crossrefType "journal-article" @default.
- W31419984 hasAuthorship W31419984A5005797727 @default.
- W31419984 hasAuthorship W31419984A5010231747 @default.
- W31419984 hasAuthorship W31419984A5028850387 @default.
- W31419984 hasAuthorship W31419984A5032413566 @default.
- W31419984 hasAuthorship W31419984A5032447495 @default.
- W31419984 hasAuthorship W31419984A5049660576 @default.
- W31419984 hasAuthorship W31419984A5063838301 @default.
- W31419984 hasConcept C126322002 @default.
- W31419984 hasConcept C134018914 @default.
- W31419984 hasConcept C138976137 @default.
- W31419984 hasConcept C164705383 @default.
- W31419984 hasConcept C198710026 @default.
- W31419984 hasConcept C2776370428 @default.
- W31419984 hasConcept C2778069365 @default.
- W31419984 hasConcept C2778198053 @default.
- W31419984 hasConcept C2778525890 @default.
- W31419984 hasConcept C2778849806 @default.
- W31419984 hasConcept C2908929049 @default.
- W31419984 hasConcept C2911091166 @default.
- W31419984 hasConcept C37557685 @default.
- W31419984 hasConcept C63645605 @default.
- W31419984 hasConcept C71924100 @default.
- W31419984 hasConcept C84393581 @default.
- W31419984 hasConceptScore W31419984C126322002 @default.
- W31419984 hasConceptScore W31419984C134018914 @default.
- W31419984 hasConceptScore W31419984C138976137 @default.
- W31419984 hasConceptScore W31419984C164705383 @default.
- W31419984 hasConceptScore W31419984C198710026 @default.
- W31419984 hasConceptScore W31419984C2776370428 @default.
- W31419984 hasConceptScore W31419984C2778069365 @default.
- W31419984 hasConceptScore W31419984C2778198053 @default.
- W31419984 hasConceptScore W31419984C2778525890 @default.
- W31419984 hasConceptScore W31419984C2778849806 @default.
- W31419984 hasConceptScore W31419984C2908929049 @default.
- W31419984 hasConceptScore W31419984C2911091166 @default.
- W31419984 hasConceptScore W31419984C37557685 @default.
- W31419984 hasConceptScore W31419984C63645605 @default.
- W31419984 hasConceptScore W31419984C71924100 @default.
- W31419984 hasConceptScore W31419984C84393581 @default.
- W31419984 hasIssue "9" @default.
- W31419984 hasLocation W314199841 @default.
- W31419984 hasOpenAccess W31419984 @default.
- W31419984 hasPrimaryLocation W314199841 @default.
- W31419984 hasRelatedWork W1996090339 @default.
- W31419984 hasRelatedWork W2016647631 @default.
- W31419984 hasRelatedWork W2063295619 @default.
- W31419984 hasRelatedWork W2105049669 @default.
- W31419984 hasRelatedWork W2151364184 @default.
- W31419984 hasRelatedWork W2163288483 @default.
- W31419984 hasRelatedWork W2237110052 @default.
- W31419984 hasRelatedWork W2420688480 @default.
- W31419984 hasRelatedWork W31419984 @default.
- W31419984 hasRelatedWork W837895513 @default.
- W31419984 hasVolume "15" @default.
- W31419984 isParatext "false" @default.
- W31419984 isRetracted "false" @default.
- W31419984 magId "31419984" @default.
- W31419984 workType "article" @default.