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- W3142002136 abstract "AIM To domesticate and identify canine distemper virus as a candidate for vaccine strain. METHOD The epidemic attenuate canine distemper virus was passage 110(times)according to the following process: Via Chick chorioallantoic membrane to MA104 cells→Vero cells→MDCK cells, then to MA104 cells, during which the attenuate strain was cloned and the TCID 50 was assayed titer in every passage. The obtained attenuate stra+in(named CDV XN 112 )was observed under the electron microscope and tested with the immunogenicity, heredity vaccinating quantity of the virus culture temperature, vaccinating method and revolving velocity of culturing cells with rotation ball. RESULTS The isolated epidemic attenuate strain of vaccine distemper virus lost its pathogenicity to dogs after being domesticated to 90 passages, and the TCID 50 titer was 10 -5.5 · mL -1 . The toxic strain by negative staining had the typical structure of canine distemper virus under electron microscope and there was a clear bridge link frame between the rabbit anti CDV XN 112 IgG and virus of Onder Stepoot. Its SN could reach 512.Among CDV XN 112 , SH CDV and OnderStepoot CDV, there existed,to some different extent, cross neutralizations. During passage of MA104,no reversion was found. CONCLUSION CDV XN 112 Strain could be a candidate for attenuate vaccine strain." @default.
- W3142002136 created "2021-04-13" @default.
- W3142002136 creator A5063481044 @default.
- W3142002136 date "2000-01-01" @default.
- W3142002136 modified "2023-09-26" @default.
- W3142002136 title "Domestication and identification of canine distemper virus epidemic strain" @default.
- W3142002136 hasPublicationYear "2000" @default.
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