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- W3142014815 abstract "<b><i>Objective:</i></b> To investigate patient-reported outcome (PRO) usage in phase I oncology clinical trials, including types of PRO measures and changes over time. <b><i>Methods:</i></b> We analyzed ClinicalTrials.gov records of phase I oncology clinical trials completed by December 2019. <b><i>Results:</i></b> Of all eligible trials, 2.3% (129/5,515) reported ≥1 PRO, totaling 181 instances of PRO usage. PRO usage increased over time, from 0.6% (trials initiated before 2000) to 3.4% (trials starting between 2015 and 2019). The most common PRO measures were unspecified (29%), tumor-specific (24%), and generic cancer (19%). <b><i>Conclusion:</i></b> Although uncommon in phase I oncology clinical trials, PRO usage is increasing over time. PRO measures were often unspecified on ClinicalTrials.gov, suggesting that more precise reporting and standardization are needed." @default.
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- W3142014815 date "2021-01-01" @default.
- W3142014815 modified "2023-10-02" @default.
- W3142014815 title "The Use of Patient-Reported Outcome Measures in Phase I Oncology Clinical Trials" @default.
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- W3142014815 doi "https://doi.org/10.1159/000514874" @default.
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