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- W3142079400 abstract "Objective To investigate the protective and therapeutic effects of pinacidil on hypoxia-inducedpulmonary hypertension(HPH) and pulmonary vascular remodeling.Methods 46 male Wister rats were divided into control group, hypoxic group and treated group (hypoxic rat treated with pinacidil for 4 weeks). Rat models with chronic HPH were established by chronic hypobaric hypoxia [(10 ± 0.5)% O2,4 weeks)]. The mean pulmonary arterial pressure (mPAP) and right ventricle /left ventricle and septum [RV/(LV + S) ]were measured and the small pulmonary arterial morphologic changes were observed with morphmetric analysis under microscopes in three groups. Results (1) The level of mPAP(28.4± 2.8) mm Hg and RV/(LV+ S)(0.30± 0.03) were significantly higher in the hypoxic group than (16.2 ± 1.8) mm Hg and (0.22 ± 0.03) in control group respectively (P 0.01). Morphometry investigation showed that the extrnal diameter became smaller and that ratio of vascular wall thickness to external diameter (MT% ) (25.7 ± 2.6) % and ratio of vascular wall area to total area (MA% )(75.3 ± 5.6)% significantly increased in the typoxic group. (2) The mPAP(23.3 ± 2.6) mm Hg, RV/(LV + S) (0.27 ± 0.04)and pulmonary vascular pathlogic changes MT%(22. 1 ± 2.5) % and MA% (67.0 ± 6. 1) % significantly decreased in the treated group, indicating that pinacidil inhibital HPH and hypoxia-induced thickening and muscularization of small pulmonary arteria. Conclusion pinacidil may partly prevent the development of HPH and pulmonary vascular remodeling." @default.
- W3142079400 created "2021-04-13" @default.
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- W3142079400 date "2000-01-01" @default.
- W3142079400 modified "2023-09-23" @default.
- W3142079400 title "Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension" @default.
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