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• W3142096029 abstract "OBJECTIVES: Fusogenic liposomes are particulate drug delivery systems which deliver encapsulated content into the cell cytosol efficiently, and it was confirmed that these liposomes are suitable carriers for macromolecules such as DNA, proteins and polysaccharides. The aim of this study was to prepare fusogenic liposome as a drug delivery carrier for CyA. METHODS: In this study liposomes containing CyA were prepared by using dipalmitoylphosphatidylcholine (DPPC) and cholesterol via solvent evaporation method and for fusogenic liposomes dioleoylphosphatidylethanolamine (DOPE) was added to the formulation. For sizing of liposomes, polycarbonate filters with exact size of 1000, 400 and 100 nm were used. For liposome characterization, liposome size was determined by using particle size analyzer and encapsulation percent was evaluated during two months. Finally in vitro immunosuppressive effects of liposomes and aqueous solution of CyA were compared on human T-cells by MTT (3- (4, 5- dimethylthiazol- 2-yl)-2, 5-diphenyl tetrazolium bromide) test. RESULTS: Light microscopic evaluation of the liposome formulations showed that the liposomes are multi lamellar vesicle (MLV). The sizes of non-fusogenic and fusogenic liposomes were 1.760±0.006 and 2.122±0.004 µm, and their percent of encapsulation were 79.71±3.00 and 85.67±9.46 %, respectively. In vitro immunosuppressive evaluation by T-cell culture was showed that fusogenic liposomes have more inhibitory effects on T-cell proliferation than non-fusogenic liposome and aqueous solution of CyA. IC50 of MLV, 1000, 400 and 100 nm of fusogenic liposomes were 6.151×10 -6 , 4.123×10 -5 , 1.461×10 -4 and 1.276×10 -4 mM, respectively. CONCLUSION: In this study" @default.
• W3142096029 created "2021-04-13" @default.
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• W3142096029 date "2005-01-01" @default.
• W3142096029 modified "2023-09-27" @default.
• W3142096029 title "Preparation of fusogenic liposomes encapsulated with cyclosporine A and evaluation of its immunosuppressive effects on human T-cells" @default.
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