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- W3142133884 abstract "Objective CYP2E1 is one of the major drug metabolic enzymes in the liver.The effect of flavonoids extract from apocynum venetum tea(AVE) on CYP2E1 activity and expression in mice were investigated by in vitro and in vivo experiments.Methods The mice were randomly separated to 3 groups,control group,low dose- and high dose AVE(50 and 100 mg/kg,respectively),and the AVE were administered using an intragastric tube once daily for 10 days.Catalytic activity of CYP2E1 in liver microsome was measured by using probe drugs method,and nitrophenol was used as the probe substrate.The expression of CYP2E1 protein in liver microsome was detected using Western blot method.In the in vitro inhibition experiments,liver microsome was incubated with different concentrations of flavonoids extract,and the 50%inhibitory concentration(IC_(50)) value of AVE on CYP2E1 was calculated.Results After fed with high dose of AVE(100 mg/kg),CYP2E1 activity and expression in mice were significantly reduced comparing to the control group,and IC_(50) of AVE on CYP2E1 was 128.4 ng/mL.Conclusion Flavonoids extract from apocynum tea efifectively inhibits CYP2E1 in mice." @default.
- W3142133884 created "2021-04-13" @default.
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- W3142133884 date "2014-01-01" @default.
- W3142133884 modified "2023-09-24" @default.
- W3142133884 title "Effect of flavonoids extract from apocynum venetum tea on CYP2E1 in mice" @default.
- W3142133884 hasPublicationYear "2014" @default.
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