Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142202310> ?p ?o ?g. }
- W3142202310 endingPage "3474" @default.
- W3142202310 startingPage "3474" @default.
- W3142202310 abstract "As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients." @default.
- W3142202310 created "2021-04-13" @default.
- W3142202310 creator A5005137718 @default.
- W3142202310 creator A5007787317 @default.
- W3142202310 creator A5023671070 @default.
- W3142202310 creator A5024350156 @default.
- W3142202310 creator A5024899922 @default.
- W3142202310 creator A5034879633 @default.
- W3142202310 creator A5042430456 @default.
- W3142202310 creator A5044174065 @default.
- W3142202310 creator A5045479314 @default.
- W3142202310 creator A5050579307 @default.
- W3142202310 creator A5053348898 @default.
- W3142202310 creator A5054101072 @default.
- W3142202310 creator A5072335274 @default.
- W3142202310 creator A5080471419 @default.
- W3142202310 creator A5085415520 @default.
- W3142202310 creator A5086592438 @default.
- W3142202310 creator A5091122881 @default.
- W3142202310 date "2021-03-27" @default.
- W3142202310 modified "2023-10-18" @default.
- W3142202310 title "BRAF Gene and Melanoma: Back to the Future" @default.
- W3142202310 cites W135216053 @default.
- W3142202310 cites W1529003705 @default.
- W3142202310 cites W1543684037 @default.
- W3142202310 cites W1882891727 @default.
- W3142202310 cites W1900973458 @default.
- W3142202310 cites W1943023403 @default.
- W3142202310 cites W1950829641 @default.
- W3142202310 cites W1965370740 @default.
- W3142202310 cites W1970039331 @default.
- W3142202310 cites W1971750711 @default.
- W3142202310 cites W1974785046 @default.
- W3142202310 cites W1975131304 @default.
- W3142202310 cites W1976296101 @default.
- W3142202310 cites W1979188008 @default.
- W3142202310 cites W1984649300 @default.
- W3142202310 cites W1990435553 @default.
- W3142202310 cites W1991718664 @default.
- W3142202310 cites W1994091885 @default.
- W3142202310 cites W2003402062 @default.
- W3142202310 cites W2006559495 @default.
- W3142202310 cites W2006985176 @default.
- W3142202310 cites W2015062793 @default.
- W3142202310 cites W2017771787 @default.
- W3142202310 cites W2021505095 @default.
- W3142202310 cites W2028752124 @default.
- W3142202310 cites W2035640092 @default.
- W3142202310 cites W2036496393 @default.
- W3142202310 cites W2039482998 @default.
- W3142202310 cites W2039913198 @default.
- W3142202310 cites W2040286515 @default.
- W3142202310 cites W2040474892 @default.
- W3142202310 cites W2041406428 @default.
- W3142202310 cites W2052005627 @default.
- W3142202310 cites W2055246997 @default.
- W3142202310 cites W2055624262 @default.
- W3142202310 cites W2060160635 @default.
- W3142202310 cites W2068538563 @default.
- W3142202310 cites W2072528578 @default.
- W3142202310 cites W2076424556 @default.
- W3142202310 cites W2084965383 @default.
- W3142202310 cites W2087835012 @default.
- W3142202310 cites W2094481139 @default.
- W3142202310 cites W2096387850 @default.
- W3142202310 cites W2098236219 @default.
- W3142202310 cites W2102584939 @default.
- W3142202310 cites W2106578635 @default.
- W3142202310 cites W2107693762 @default.
- W3142202310 cites W2108480019 @default.
- W3142202310 cites W2110764732 @default.
- W3142202310 cites W2114108194 @default.
- W3142202310 cites W2116376943 @default.
- W3142202310 cites W2117247812 @default.
- W3142202310 cites W2121377606 @default.
- W3142202310 cites W2121545342 @default.
- W3142202310 cites W2121820529 @default.
- W3142202310 cites W2124662474 @default.
- W3142202310 cites W2128327828 @default.
- W3142202310 cites W2128542677 @default.
- W3142202310 cites W2132992059 @default.
- W3142202310 cites W2135925159 @default.
- W3142202310 cites W2142658272 @default.
- W3142202310 cites W2144169031 @default.
- W3142202310 cites W2144303933 @default.
- W3142202310 cites W2149071620 @default.
- W3142202310 cites W2149576348 @default.
- W3142202310 cites W2152061559 @default.
- W3142202310 cites W2163188200 @default.
- W3142202310 cites W2166229764 @default.
- W3142202310 cites W2167925208 @default.
- W3142202310 cites W2169133530 @default.
- W3142202310 cites W2206684187 @default.
- W3142202310 cites W2219817965 @default.
- W3142202310 cites W2254060056 @default.
- W3142202310 cites W2281646699 @default.
- W3142202310 cites W2299181842 @default.
- W3142202310 cites W2337488576 @default.