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- W3142204690 abstract "Salvicine 是一混合物由与对在 vitro 并且在忍受人的 tumorxenografts.Salvicine 的老鼠的大量人的肿瘤房间的禁止的活动也被发现了有深刻细胞毒素的效果 onmultidrug-resisitant 的有势力生长从中国植物孤立的自然产品领先的结构的修正获得了的一个新奇 diterpenoid 五人一组( MDR ) cells.Moreover ， Salvicine 显著地减少了肺变形 foci ofMDA-MB-435 orthotopic 异种皮移植。最近的研究证明 salvicine 是 novelnon-intercalative topoisomerase II (Topo II ) 由到 ATPase 域的绑定的毒物，支持 DNA-TopoII 有约束力、禁止的 Topo 调停 II 的 DNA 驱逐和 ATP 水解作用。进一步的研究显示了得到 salcivine 的 ROS 包括 Topo II 抑制， DNA 损坏，围绕的 MDR 和肿瘤在导致 salvicine 的细胞的反应起一个中央作用房间粘附抑制。" @default.
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- W3142204690 date "2007-01-01" @default.
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- W3142204690 title "Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation" @default.
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