FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142238688> ?p ?o ?g. }

• W3142238688 abstract "A B S T R A C T The mode of action of the hypocholesteremic drug neomycin (2 g/day) was studied in four patients. All showed a significant reduction in plasma cholesterol concentrations (mean 25%, range 18-31%), and in one of three patients with hyperglyceridemia there was a decrease of plasma triglycerides of 26%. Cholesterol absorption was measured in three of four patients: there was a marked decrease. Sterol balance studies in four patients showed an unabating increase in fecal neutral steroid excretion (mean increase 345 mg/ day, range 323-361) for 3-5 wk after plasma cholesterol levels had reached a new and lower plateau. Fecal acidic steroid excretion increased temporarily in two patients, with a sustained increase of 93 mg/day in only one. Daily stool weights increased significantly in three of four patients, though none had steatorrhea; there was a significant reduction in excretion of secondary bile acids; neutral sterol degradation rates were not affected by the drug. Slopes of plasma cholesterolspecific activity time curves did not change. These results fail to support the suggestion that neomycin acts as a bile acid precipitant. The finding of increased fecal neutral steroid excretion is consistent with decreased cholesterol absorption, but also with increased cholesterol synthesis (secondary to release of negative feedback control), with increased flux of cholesterol from tissues, or with a combination of all three actions." @default.
• W3142238688 created "2021-04-13" @default.
• W3142238688 creator A5000463229 @default.
• W3142238688 date "1975-01-01" @default.
• W3142238688 modified "2023-09-24" @default.
• W3142238688 title "Effects of Neomycin on Absorption, Synthesis, and/or Flux of Cholesterol in Man" @default.
• W3142238688 cites W1426259424 @default.
• W3142238688 cites W1724717216 @default.
• W3142238688 cites W1879297302 @default.
• W3142238688 cites W1962620101 @default.
• W3142238688 cites W1966441156 @default.
• W3142238688 cites W1995514808 @default.
• W3142238688 cites W2023534283 @default.
• W3142238688 cites W2027400090 @default.
• W3142238688 cites W2029811220 @default.
• W3142238688 cites W2031070752 @default.
• W3142238688 cites W2036295891 @default.
• W3142238688 cites W2063403416 @default.
• W3142238688 cites W2071474862 @default.
• W3142238688 cites W2077706224 @default.
• W3142238688 cites W2077912673 @default.
• W3142238688 cites W2092385431 @default.
• W3142238688 cites W2111465437 @default.
• W3142238688 cites W2113837794 @default.
• W3142238688 cites W2130232249 @default.
• W3142238688 cites W2138232781 @default.
• W3142238688 cites W2143813160 @default.
• W3142238688 cites W2147973062 @default.
• W3142238688 cites W2162719733 @default.
• W3142238688 cites W2165197266 @default.
• W3142238688 cites W2167691752 @default.
• W3142238688 cites W2182413963 @default.
• W3142238688 cites W2184365605 @default.
• W3142238688 cites W2207355009 @default.
• W3142238688 cites W2314025995 @default.
• W3142238688 cites W2314766391 @default.
• W3142238688 cites W2317740773 @default.
• W3142238688 cites W2326510067 @default.
• W3142238688 cites W2398111455 @default.
• W3142238688 cites W2400696180 @default.
• W3142238688 cites W2408526630 @default.
• W3142238688 cites W2414121512 @default.
• W3142238688 cites W2433705576 @default.
• W3142238688 cites W2467983990 @default.
• W3142238688 cites W580091838 @default.
• W3142238688 hasPublicationYear "1975" @default.
• W3142238688 type Work @default.
• W3142238688 sameAs 3142238688 @default.
• W3142238688 citedByCount "0" @default.
• W3142238688 crossrefType "journal-article" @default.
• W3142238688 hasAuthorship W3142238688A5000463229 @default.
• W3142238688 hasConcept C10146269 @default.
• W3142238688 hasConcept C121332964 @default.
• W3142238688 hasConcept C125287762 @default.
• W3142238688 hasConcept C126322002 @default.
• W3142238688 hasConcept C134018914 @default.
• W3142238688 hasConcept C151730666 @default.
• W3142238688 hasConcept C185592680 @default.
• W3142238688 hasConcept C24890656 @default.
• W3142238688 hasConcept C2777675875 @default.
• W3142238688 hasConcept C2778163477 @default.
• W3142238688 hasConcept C2778697171 @default.
• W3142238688 hasConcept C2778718757 @default.
• W3142238688 hasConcept C2779399885 @default.
• W3142238688 hasConcept C2779841869 @default.
• W3142238688 hasConcept C2780902042 @default.
• W3142238688 hasConcept C501593827 @default.
• W3142238688 hasConcept C55493867 @default.
• W3142238688 hasConcept C61716771 @default.
• W3142238688 hasConcept C71315377 @default.
• W3142238688 hasConcept C71924100 @default.
• W3142238688 hasConcept C86803240 @default.
• W3142238688 hasConceptScore W3142238688C10146269 @default.
• W3142238688 hasConceptScore W3142238688C121332964 @default.
• W3142238688 hasConceptScore W3142238688C125287762 @default.
• W3142238688 hasConceptScore W3142238688C126322002 @default.
• W3142238688 hasConceptScore W3142238688C134018914 @default.
• W3142238688 hasConceptScore W3142238688C151730666 @default.
• W3142238688 hasConceptScore W3142238688C185592680 @default.
• W3142238688 hasConceptScore W3142238688C24890656 @default.
• W3142238688 hasConceptScore W3142238688C2777675875 @default.
• W3142238688 hasConceptScore W3142238688C2778163477 @default.
• W3142238688 hasConceptScore W3142238688C2778697171 @default.
• W3142238688 hasConceptScore W3142238688C2778718757 @default.
• W3142238688 hasConceptScore W3142238688C2779399885 @default.
• W3142238688 hasConceptScore W3142238688C2779841869 @default.
• W3142238688 hasConceptScore W3142238688C2780902042 @default.
• W3142238688 hasConceptScore W3142238688C501593827 @default.
• W3142238688 hasConceptScore W3142238688C55493867 @default.
• W3142238688 hasConceptScore W3142238688C61716771 @default.
• W3142238688 hasConceptScore W3142238688C71315377 @default.
• W3142238688 hasConceptScore W3142238688C71924100 @default.
• W3142238688 hasConceptScore W3142238688C86803240 @default.
• W3142238688 hasLocation W31422386881 @default.
• W3142238688 hasOpenAccess W3142238688 @default.
• W3142238688 hasPrimaryLocation W31422386881 @default.
• W3142238688 hasRelatedWork W1531152636 @default.
• W3142238688 hasRelatedWork W1979800548 @default.
• W3142238688 hasRelatedWork W1982890029 @default.
• W3142238688 hasRelatedWork W1986735477 @default.

• next