FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142247350> ?p ?o ?g. }

• W3142247350 abstract "Abstract Transmissible cancers are parasitic malignant cell lineages that acquired the ability to infect new hosts from the same species, or sometimes related species. First described in dogs and Tasmanian devils, transmissible cancers were later discovered in some marine bivalves affected by a leukemia-like disease. In Mytilus mussels, two lineages of Bivalve Transmissible Neoplasia (BTN), both emerged in a M. trossulus founder individual, have been described to date (MtrBTN1 and MtrBTN2). Here, we performed an extensive screening of genetic chimerism, a hallmark of transmissible cancer, by genotyping hundred SNPs of thousands of European Mytilus mussels. The genetic analysis allowed us to simultaneously obtain the genotype of hosts -M. edulis , M. galloprovincialis or hybrids- and the genotype of tumors of heavily infected individuals. In addition, a subset of individuals were systematically genotyped and analysed by histology in order to screen for possible non-transmissible cancers. We detected MtrBTN2 at low prevalence in M. edulis , and also in M. galloprovincialis and hybrids although at a much lower prevalence. No MtrBTN1 or new BTN were found but a few individuals with non-transmissible neoplasia were observed at a single polluted site on the same sampling date. We observed a diversity of MtrBTN2 genotypes that appeared more introgressed or more ancestral than MtrBTN1 and reference healthy M. trossulus individuals. The observed polymorphism is most likely due to somatic null alleles caused by structural variations or point mutations in primer-binding sites leading to enhanced detection of the host alleles. Despite low prevalence, two divergent sublineages, confirmed by mtCOI sequences, are co-spreading in the same geographic area, suggesting a complex diversification of MtrBTN2 since its emergence and host species shift." @default.
• W3142247350 created "2021-04-13" @default.
• W3142247350 creator A5012634831 @default.
• W3142247350 creator A5014797249 @default.
• W3142247350 creator A5016078204 @default.
• W3142247350 creator A5019767459 @default.
• W3142247350 creator A5024320805 @default.
• W3142247350 creator A5031753978 @default.
• W3142247350 creator A5038127077 @default.
• W3142247350 creator A5047696214 @default.
• W3142247350 creator A5050519987 @default.
• W3142247350 creator A5057275312 @default.
• W3142247350 creator A5066955907 @default.
• W3142247350 creator A5071700583 @default.
• W3142247350 creator A5076046741 @default.
• W3142247350 creator A5085789609 @default.
• W3142247350 creator A5089316156 @default.
• W3142247350 date "2021-04-01" @default.
• W3142247350 modified "2023-10-14" @default.
• W3142247350 title "Prevalence and polymorphism of a mussel transmissible cancer in Europe" @default.
• W3142247350 cites W1972158413 @default.
• W3142247350 cites W1981770389 @default.
• W3142247350 cites W1982214613 @default.
• W3142247350 cites W1984266682 @default.
• W3142247350 cites W1993096431 @default.
• W3142247350 cites W1999923224 @default.
• W3142247350 cites W2002710022 @default.
• W3142247350 cites W2004970696 @default.
• W3142247350 cites W2006394648 @default.
• W3142247350 cites W2013425754 @default.
• W3142247350 cites W2026606177 @default.
• W3142247350 cites W2031266176 @default.
• W3142247350 cites W2032390031 @default.
• W3142247350 cites W2038501888 @default.
• W3142247350 cites W2040197913 @default.
• W3142247350 cites W2043929255 @default.
• W3142247350 cites W2078238640 @default.
• W3142247350 cites W2085560980 @default.
• W3142247350 cites W2102636611 @default.
• W3142247350 cites W2108234281 @default.
• W3142247350 cites W2112388098 @default.
• W3142247350 cites W2116585889 @default.
• W3142247350 cites W2128786960 @default.
• W3142247350 cites W2139723360 @default.
• W3142247350 cites W2154319440 @default.
• W3142247350 cites W2156057520 @default.
• W3142247350 cites W2187273062 @default.
• W3142247350 cites W2268032294 @default.
• W3142247350 cites W2283995236 @default.
• W3142247350 cites W2288271511 @default.
• W3142247350 cites W2303656007 @default.
• W3142247350 cites W2311203695 @default.
• W3142247350 cites W2412993260 @default.
• W3142247350 cites W2469746193 @default.
• W3142247350 cites W2521869329 @default.
• W3142247350 cites W2529178107 @default.
• W3142247350 cites W2659524178 @default.
• W3142247350 cites W2734829443 @default.
• W3142247350 cites W2761351147 @default.
• W3142247350 cites W2789399660 @default.
• W3142247350 cites W2795160934 @default.
• W3142247350 cites W2849190269 @default.
• W3142247350 cites W2886097315 @default.
• W3142247350 cites W2886822608 @default.
• W3142247350 cites W2907174442 @default.
• W3142247350 cites W2966830776 @default.
• W3142247350 cites W2969864171 @default.
• W3142247350 cites W2971559821 @default.
• W3142247350 cites W2980367764 @default.
• W3142247350 cites W2981312973 @default.
• W3142247350 cites W2988132553 @default.
• W3142247350 cites W2995487235 @default.
• W3142247350 cites W3009339878 @default.
• W3142247350 cites W3014884007 @default.
• W3142247350 cites W3092195745 @default.
• W3142247350 cites W3108416161 @default.
• W3142247350 cites W3112457174 @default.
• W3142247350 cites W3113549781 @default.
• W3142247350 cites W3122995267 @default.
• W3142247350 cites W4232976117 @default.
• W3142247350 cites W782155171 @default.
• W3142247350 doi "https://doi.org/10.1101/2021.03.31.436483" @default.
• W3142247350 hasPublicationYear "2021" @default.
• W3142247350 type Work @default.
• W3142247350 sameAs 3142247350 @default.
• W3142247350 citedByCount "0" @default.
• W3142247350 crossrefType "posted-content" @default.
• W3142247350 hasAuthorship W3142247350A5012634831 @default.
• W3142247350 hasAuthorship W3142247350A5014797249 @default.
• W3142247350 hasAuthorship W3142247350A5016078204 @default.
• W3142247350 hasAuthorship W3142247350A5019767459 @default.
• W3142247350 hasAuthorship W3142247350A5024320805 @default.
• W3142247350 hasAuthorship W3142247350A5031753978 @default.
• W3142247350 hasAuthorship W3142247350A5038127077 @default.
• W3142247350 hasAuthorship W3142247350A5047696214 @default.
• W3142247350 hasAuthorship W3142247350A5050519987 @default.
• W3142247350 hasAuthorship W3142247350A5057275312 @default.
• W3142247350 hasAuthorship W3142247350A5066955907 @default.
• W3142247350 hasAuthorship W3142247350A5071700583 @default.
• W3142247350 hasAuthorship W3142247350A5076046741 @default.

• next