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- W3142271207 abstract "AIM To investigate the characteristics of alcohol-preferring behavior in FH/Wjd rats. METHODS Two-bottle free choice test (5% or 10% ethanol and tap water) was employed to determine the ethanol intake,water intake and ethanol preference,through which the day-night difference of ethanol drinking in FH/Wjd rats was explored. In ethanol deprivation experiment,the effects of 24 h deprivation on ethanol intake and preference in FH/Wjd rats were measured. The operant ethanol self-administration of FH/Wjd rats was observed under fixed ratio (FR1) procedure. RESULTS In two-bottle test,the daily ethanol intake,water intake,and ethanol preference of FH/Wjd rats were (4.3±0.2)g·kg-1·d-1,(20.1±2.3)g·kg-1·d-1,and (82.9±2.0)%,respectively in 5% ethanol group and (6.4± 0.2)g·kg-1·d-1,(37.2±2.7)g·kg-1·d-1 and (69.2±2.0)%,respectively in 10% ethanol group. It demonstrated the ethanol and water intake of FH/Wjd rats in 10% ethanol group was more,but the ethanol preference of them was lower than those in 5%ethanol group. The ethanol intake and preference of FH/Wjd rats in night were higher than that in day. There was no day-night difference in water intake. Ethanol deprivation for 24 h produced a significant increase in ethanol intake and ethanol preference in the first hour and 24 h of re-access in FH/Wjd rats. They also substantially increased their ethanol preference in the first hour but not 24 h of re-exposed to ethanol. After 13 training days,the preference of operant ethanol self-administration of FH/Wjd rats was 49%-64% during 3 test days,which demonstrated that ethanol seeking behavior was successfully established in FH/Wjd rats. CONCLUSION FH/Wjd rats which showed high ethanol intake and preference,robust ethanol deprivation effect,and could develop operant ethanol self-administration behavior in short time,can be used as a genetic animal model of alcoholism." @default.
- W3142271207 created "2021-04-13" @default.
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- W3142271207 date "2009-01-01" @default.
- W3142271207 modified "2023-09-25" @default.
- W3142271207 title "Characteristics of alcohol-preferring behavior in FH/Wjd rats" @default.
- W3142271207 hasPublicationYear "2009" @default.
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