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• W3142284405 abstract "Free fatty acid receptors (FFARs) are a class of G protein-coupled receptors (GPCRs) that have wide-ranging effects on human physiology. The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. Short-chain (&lt;6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41. Medium- and long-chain fatty acids (6–12 and 13–21 carbon, respectively) target both FFAR1/GPR40 and FFAR4/GPR120. Signaling through FFARs has been implicated in non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), intestinal failure-associated liver disease (IFALD), and a variety of other liver disorders. FFARs are now regarded as targets for therapeutic intervention for liver disease, diabetes, obesity, hyperlipidemia, and metabolic syndrome. In this review, we provide an in-depth, focused summary of the role FFARs play in liver health and disease." @default.
• W3142284405 created "2021-04-13" @default.
• W3142284405 creator A5004265812 @default.
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• W3142284405 date "2021-04-07" @default.
• W3142284405 modified "2023-10-12" @default.
• W3142284405 title "Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease" @default.
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• W3142284405 doi "https://doi.org/10.3389/fphys.2021.656441" @default.
• W3142284405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8058363" @default.
• W3142284405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33897464" @default.
• W3142284405 hasPublicationYear "2021" @default.
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