Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142304501> ?p ?o ?g. }
- W3142304501 endingPage "430" @default.
- W3142304501 startingPage "417" @default.
- W3142304501 abstract "To perform therapeutic drug monitoring (TDM) of total and free plasma valproic acid (VPA) concentrations in pediatric patients with epilepsy and to analyze related factors.Pediatric epileptic patients treated in 2015-2019 in our hospital were assessed. Total and free plasma VPA concentrations were obtained by UPLC and LC-MS/MS, respectively. Regression analysis was performed to examine the associations of free plasma VPA with total plasma VPA and plasma protein binding rate. The impacts of individual situation, CYP2C9 genotype, and drug combination on VPA concentration were examined.Of the 251 patients, 81 had lower total concentrations than effective therapeutic levels; 86 and 31 patients had infections and central nervous system dysplasia, respectively. VPA's daily doses and free drug concentrations were significantly lower in the CYP2C9 *3/*3 genotype group versus the CYP2C9 *1/*3 and CYP2C9 *1/*1 groups (P<0.05). Free and total VPA concentrations were linked by Y = 0.0004 X2 + 0.042 X + 0.3035 (r=0.6981); VPA plasma protein binding rate and free VPA concentration were related by Y = 0.0003 X2 - 0.0127 X + 0.9777 (r=0.8136). Both total and free VPA concentrations were significantly decreased in patients simultaneously administered phenobarbital, meropenem and biapenem (P<0.05), with therapeutic failure after meropenem/biapenem co-administration.Free VPA amounts have nonlinear relationships with total VPA amounts and plasma protein binding rate in epileptic children. Additionally, CYP2C9 *3/*3 expression affects VPA metabolism. Since phenobarbital affects VPA metabolism, TDM is recommended. Meanwhile, carbapenem-co-administration with VPA should be prohibited." @default.
- W3142304501 created "2021-04-13" @default.
- W3142304501 creator A5006794114 @default.
- W3142304501 creator A5014233085 @default.
- W3142304501 creator A5015579959 @default.
- W3142304501 creator A5024154589 @default.
- W3142304501 creator A5032142239 @default.
- W3142304501 creator A5039444574 @default.
- W3142304501 creator A5060330097 @default.
- W3142304501 date "2021-04-01" @default.
- W3142304501 modified "2023-10-15" @default.
- W3142304501 title "CYP2C9*3/*3 Gene Expression Affects the Total and Free Concentrations of Valproic Acid in Pediatric Patients with Epilepsy" @default.
- W3142304501 cites W1966380764 @default.
- W3142304501 cites W1967508559 @default.
- W3142304501 cites W1982677579 @default.
- W3142304501 cites W1987517247 @default.
- W3142304501 cites W1991348749 @default.
- W3142304501 cites W2017898520 @default.
- W3142304501 cites W2025949427 @default.
- W3142304501 cites W2027346156 @default.
- W3142304501 cites W2027852910 @default.
- W3142304501 cites W2034960352 @default.
- W3142304501 cites W2038826755 @default.
- W3142304501 cites W2044939869 @default.
- W3142304501 cites W2085076307 @default.
- W3142304501 cites W2094089029 @default.
- W3142304501 cites W2102338788 @default.
- W3142304501 cites W2106862896 @default.
- W3142304501 cites W2117039119 @default.
- W3142304501 cites W2120869603 @default.
- W3142304501 cites W2126332685 @default.
- W3142304501 cites W2140325242 @default.
- W3142304501 cites W2140682831 @default.
- W3142304501 cites W2154447677 @default.
- W3142304501 cites W2312616498 @default.
- W3142304501 cites W2424512182 @default.
- W3142304501 cites W2426518104 @default.
- W3142304501 cites W2461355871 @default.
- W3142304501 cites W2494046869 @default.
- W3142304501 cites W2586543557 @default.
- W3142304501 cites W2592683324 @default.
- W3142304501 cites W2593772135 @default.
- W3142304501 cites W2618094398 @default.
- W3142304501 cites W2751135919 @default.
- W3142304501 cites W2754294636 @default.
- W3142304501 cites W2767324807 @default.
- W3142304501 cites W2773319064 @default.
- W3142304501 cites W2802644563 @default.
- W3142304501 cites W2895148708 @default.
- W3142304501 cites W2896032127 @default.
- W3142304501 cites W2896038274 @default.
- W3142304501 cites W2897291951 @default.
- W3142304501 cites W2906671863 @default.
- W3142304501 cites W2933874374 @default.
- W3142304501 cites W2940730319 @default.
- W3142304501 cites W2945035393 @default.
- W3142304501 cites W2980753837 @default.
- W3142304501 doi "https://doi.org/10.2147/pgpm.s301893" @default.
- W3142304501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8043849" @default.
- W3142304501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33859491" @default.
- W3142304501 hasPublicationYear "2021" @default.
- W3142304501 type Work @default.
- W3142304501 sameAs 3142304501 @default.
- W3142304501 citedByCount "1" @default.
- W3142304501 countsByYear W31423045012023 @default.
- W3142304501 crossrefType "journal-article" @default.
- W3142304501 hasAuthorship W3142304501A5006794114 @default.
- W3142304501 hasAuthorship W3142304501A5014233085 @default.
- W3142304501 hasAuthorship W3142304501A5015579959 @default.
- W3142304501 hasAuthorship W3142304501A5024154589 @default.
- W3142304501 hasAuthorship W3142304501A5032142239 @default.
- W3142304501 hasAuthorship W3142304501A5039444574 @default.
- W3142304501 hasAuthorship W3142304501A5060330097 @default.
- W3142304501 hasBestOaLocation W31423045011 @default.
- W3142304501 hasConcept C112705442 @default.
- W3142304501 hasConcept C118552586 @default.
- W3142304501 hasConcept C126322002 @default.
- W3142304501 hasConcept C134018914 @default.
- W3142304501 hasConcept C19831878 @default.
- W3142304501 hasConcept C2777172819 @default.
- W3142304501 hasConcept C2778186239 @default.
- W3142304501 hasConcept C2778337148 @default.
- W3142304501 hasConcept C2778793413 @default.
- W3142304501 hasConcept C2780035454 @default.
- W3142304501 hasConcept C2780272996 @default.
- W3142304501 hasConcept C3946865 @default.
- W3142304501 hasConcept C526171541 @default.
- W3142304501 hasConcept C62231903 @default.
- W3142304501 hasConcept C71924100 @default.
- W3142304501 hasConcept C98274493 @default.
- W3142304501 hasConceptScore W3142304501C112705442 @default.
- W3142304501 hasConceptScore W3142304501C118552586 @default.
- W3142304501 hasConceptScore W3142304501C126322002 @default.
- W3142304501 hasConceptScore W3142304501C134018914 @default.
- W3142304501 hasConceptScore W3142304501C19831878 @default.
- W3142304501 hasConceptScore W3142304501C2777172819 @default.
- W3142304501 hasConceptScore W3142304501C2778186239 @default.
- W3142304501 hasConceptScore W3142304501C2778337148 @default.