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- W3142339804 abstract "Acute kidney injury (AKI) is a common complication among elderly surgical patients and is never a trivial event. Even with recovery, the odds of long-term complications, including chronic kidney disease, more frequent hospitalizations and even death are increased. Normal aging is accompanied by changes in renal structure, function, and cellular metabolism, which reduce renal reserve, delay cellular recovery, and increase the kidney’s susceptibility to all categories of AKI. This is exacerbated by comorbidities and risk factors including diabetes, atherosclerosis, and the widespread use of medications, such as nonsteroidal analgesics, and angiotensin blockers and inhibitors that alter renal compensatory mechanisms and impair the renal response to under-perfusion, which, if prolonged, can lead to ischemic injury and cell death. Widely accepted criteria which categorize the stages of renal injury have been established to define the earliest stages of renal injury, when detection and mitigation are likely to be the most effective. Although widely used, changes in the serum creatinine lag behind renal injury, and creatinine levels are an imprecise marker of cellular injury. New tools and biomarkers may prove to be clinically useful for the early detection of cellular damage, and these, together with new therapeutic strategies, may help to improve the incidence and outcomes of AKI in this high-risk population. These areas and some important ethical considerations related to the initiation of dialysis in elderly patients with AKI are explored here." @default.
- W3142339804 created "2021-04-13" @default.
- W3142339804 creator A5009072642 @default.
- W3142339804 creator A5022591058 @default.
- W3142339804 creator A5027871232 @default.
- W3142339804 creator A5057835610 @default.
- W3142339804 date "2021-01-01" @default.
- W3142339804 modified "2023-09-27" @default.
- W3142339804 title "Acute Kidney Injury in the Elderly Surgical Patient" @default.
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