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- W3142386612 abstract "Objective To investigate the levels of perforin expression in NK cells and CD8+ T lymphocytes in HIV infected individuals in China and to analyze the correlation between perforin and immune function. Methods Percentage of perforin expression in CD56+/CD3-, CD3-/CD16+ NK cells and CD8+/CD3+ lymphocytes from thirty-one untreated HIV-1 infected patients, seventeen HAART(highly active antiretroviral therapy) treated HIV/AIDS patients and 15 health controls were selected and detected by flow-cytometry intracellular stain, its correlations with NK absolute counts, NK cells percent, CD4+ T lymphocytes, CD8+ T lymphocytes and plasma viral loads were analyzed. Results The percentage of perforin-expressed NK cells(mean 13.17%, mean 24.05%) was higher than that of CD8+ T cells(mean 9.03%), perforin expression in CD8+ T lymphocytes was higher than that of health controls(P0.05), but perforin expression in NK cells was lower than that of health control(P0.05, P 0.05), their levels are not correlated with disease progression, but significantly correlated with their absolute counts; HAART can improve perforin expression in NK cells, but has no effect on CD8+ T lymphocytes. Conclusion In HIV infection the frequencies of perforin expression in NK cells were decreased, antiviral therapy can enhance their levels; perforin expression in CD8+ T lymphocytes were increased, but antiviral therapy had no significant effect on their levels." @default.
- W3142386612 created "2021-04-13" @default.
- W3142386612 creator A5074079201 @default.
- W3142386612 date "2006-01-01" @default.
- W3142386612 modified "2023-09-24" @default.
- W3142386612 title "Differential expression of perforin in cytotoxic lymphocytes in HIV infected individuals in China" @default.
- W3142386612 hasPublicationYear "2006" @default.
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