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- W3142392145 abstract "To explore the mechanism of action of the inhibitory effect of bovine pancreaticpolypeptide(BPP)on pancreatic enzyme secretion,we examined the effect of BPPon carbachol-induced amylase release from dispersed acini prepared from rat pan-creas.Results from the present study indicated that BPP could significantly inhibitamylase release from rat pancreatic acini stimulated by carbachol and this inhibi-tion was dose-dependent.In addition,BPP also inhibited carbachol-induced~(45)Ca outflux from pancreatic acini,but it had no effect on ionophore A23187-orcholecystokinin octapeptide(CCK-8)-induced ~(45)Ca outflux.These results postu-lated that BPP possessed the ability to antagonize the action of carbachol at themuscarinic cholinergic receptor level.Moreover,our results showed that BPPcould inhibit the potentiation of amylase secretion induced by secretin or vasoactiveintestinal peptide(VIP)plus carbachol.This observation suggested that theinhibitory effect of BPP on pancreatic enzyme secretion stimulated by secretinin vivo might be due to the effect of BPP in antagonizing the muscarinic choliner-gic receptors on pancreatic acinar cells,and by so doing it reduced the secretin-induced enzyme secretion which was potentiated by the cholinergic stimulant." @default.
- W3142392145 created "2021-04-13" @default.
- W3142392145 creator A5033965192 @default.
- W3142392145 date "1987-01-01" @default.
- W3142392145 modified "2023-09-24" @default.
- W3142392145 title "INHIBITORY EFFECT OF BOVINE PANCREATIC POLYPEPTIDE ON AMYLASE SECRETION——AN IN VITRO STUDY" @default.
- W3142392145 hasPublicationYear "1987" @default.
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