FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142413412> ?p ?o ?g. }

• W3142413412 endingPage "1000" @default.
• W3142413412 startingPage "1000" @default.
• W3142413412 abstract "Clozapine, the second generation antipsychotic drug, is one of the prominent compounds used for treatment of schizophrenia. Unfortunately, use of this drug is still limited due to serious side effects connected to its unspecific and non-selective action. Nevertheless, clozapine still remains the first-choice drug for the situation of drug-resistance schizophrenia. Development of the new strategy of clozapine delivery into well-defined parts of the brain has been a great challenge for modern science. In the present paper we focus on the presentation of a new nanocarrier for clozapine and its use for targeted transport, enabling its interaction with the dopamine D2 and serotonin 5-HT1A heteromers (D2-5-HT1A) in the brain tissue. Clozapine polymeric nanocapsules (CLO-NCs) were prepared using anionic surfactant AOT (sodium docusate) as an emulsifier, and bio-compatible polyelectrolytes such as: poly-l-glutamic acid (PGA) and poly-l-lysine (PLL). Outer layer of the carrier was grafted by polyethylene glycol (PEG). Several variants of nanocarriers containing the antipsychotic varying in physicochemical parameters were tested. This kind of approach may enable the availability and safety of the drug, improve the selectivity of its action, and finally increase effectiveness of schizophrenia therapy. Moreover, the purpose of the manuscript is to cover a wide scope of the issues, which should be considered while designing a novel means for drug delivery. It is important to determine the interactions of a new nanocarrier with many cell components on various cellular levels in order to be sure that the new nanocarrier will be safe and won’t cause undesired effects for a patient." @default.
• W3142413412 created "2021-04-13" @default.
• W3142413412 creator A5039130688 @default.
• W3142413412 date "2021-03-24" @default.
• W3142413412 modified "2023-09-27" @default.
• W3142413412 title "Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D2-Serotonin 5-HT1A Heteromers" @default.
• W3142413412 cites W1886379727 @default.
• W3142413412 cites W1963954117 @default.
• W3142413412 cites W1968592326 @default.
• W3142413412 cites W1972550367 @default.
• W3142413412 cites W1972706590 @default.
• W3142413412 cites W1976087970 @default.
• W3142413412 cites W1982425215 @default.
• W3142413412 cites W1988217845 @default.
• W3142413412 cites W2009179035 @default.
• W3142413412 cites W2010358008 @default.
• W3142413412 cites W2013861515 @default.
• W3142413412 cites W2015120262 @default.
• W3142413412 cites W2016097990 @default.
• W3142413412 cites W2022412433 @default.
• W3142413412 cites W2035267140 @default.
• W3142413412 cites W2041771455 @default.
• W3142413412 cites W2056616087 @default.
• W3142413412 cites W2061906593 @default.
• W3142413412 cites W2063181321 @default.
• W3142413412 cites W2064093384 @default.
• W3142413412 cites W2065172289 @default.
• W3142413412 cites W2067599429 @default.
• W3142413412 cites W2070360032 @default.
• W3142413412 cites W2078624174 @default.
• W3142413412 cites W2080774028 @default.
• W3142413412 cites W2083557320 @default.
• W3142413412 cites W2089964777 @default.
• W3142413412 cites W2095719839 @default.
• W3142413412 cites W2097727354 @default.
• W3142413412 cites W2101621191 @default.
• W3142413412 cites W2115924220 @default.
• W3142413412 cites W2117326659 @default.
• W3142413412 cites W2121361221 @default.
• W3142413412 cites W2126132542 @default.
• W3142413412 cites W2140181820 @default.
• W3142413412 cites W2140685756 @default.
• W3142413412 cites W2147761354 @default.
• W3142413412 cites W2153439840 @default.
• W3142413412 cites W2155436051 @default.
• W3142413412 cites W2165408834 @default.
• W3142413412 cites W2226799165 @default.
• W3142413412 cites W2266322781 @default.
• W3142413412 cites W2334035176 @default.
• W3142413412 cites W2416330811 @default.
• W3142413412 cites W2444197879 @default.
• W3142413412 cites W2508576968 @default.
• W3142413412 cites W2738389740 @default.
• W3142413412 cites W2785334206 @default.
• W3142413412 cites W2791362600 @default.
• W3142413412 cites W2895280172 @default.
• W3142413412 cites W2899347457 @default.
• W3142413412 cites W2910531243 @default.
• W3142413412 cites W2916793010 @default.
• W3142413412 cites W2941157893 @default.
• W3142413412 cites W2941920877 @default.
• W3142413412 cites W2948020554 @default.
• W3142413412 cites W2950765652 @default.
• W3142413412 cites W2953429358 @default.
• W3142413412 cites W2970273404 @default.
• W3142413412 cites W2973014626 @default.
• W3142413412 cites W2991057673 @default.
• W3142413412 cites W3044495494 @default.
• W3142413412 cites W3076111634 @default.
• W3142413412 cites W3091985598 @default.
• W3142413412 doi "https://doi.org/10.3390/polym13071000" @default.
• W3142413412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8036403" @default.
• W3142413412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33805130" @default.
• W3142413412 hasPublicationYear "2021" @default.
• W3142413412 type Work @default.
• W3142413412 sameAs 3142413412 @default.
• W3142413412 citedByCount "3" @default.
• W3142413412 countsByYear W31424134122022 @default.
• W3142413412 countsByYear W31424134122023 @default.
• W3142413412 crossrefType "journal-article" @default.
• W3142413412 hasAuthorship W3142413412A5039130688 @default.
• W3142413412 hasBestOaLocation W31424134121 @default.
• W3142413412 hasConcept C118552586 @default.
• W3142413412 hasConcept C171250308 @default.
• W3142413412 hasConcept C18150654 @default.
• W3142413412 hasConcept C185592680 @default.
• W3142413412 hasConcept C192562407 @default.
• W3142413412 hasConcept C2776412080 @default.
• W3142413412 hasConcept C2779820397 @default.
• W3142413412 hasConcept C2780035454 @default.
• W3142413412 hasConcept C2780864610 @default.
• W3142413412 hasConcept C71924100 @default.
• W3142413412 hasConcept C98274493 @default.
• W3142413412 hasConceptScore W3142413412C118552586 @default.
• W3142413412 hasConceptScore W3142413412C171250308 @default.
• W3142413412 hasConceptScore W3142413412C18150654 @default.
• W3142413412 hasConceptScore W3142413412C185592680 @default.
• W3142413412 hasConceptScore W3142413412C192562407 @default.

• next