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- W3142482852 abstract "Poly (D， L-lactide-co-glycolide )(PLGA ) microspheres 被乳剂溶剂蒸发准备方法。内部水的阶段的影响，器官的溶剂， microspheres 的形态学上的 PLGA 集中被学习。结果证明到内部水的阶段，器官的溶剂的类型和聚合物集中的 porogen 或表面活化剂的增加极大地影响了 microsphere 形态学。当 dichloromethane 作为器官的溶剂被采用时，有多孔的结构的 microspheres 被生产。当乙醇醋酸盐用作器官的溶剂时，二不同形态学被获得。一个人是有在更低的 PLGA 集中下面的薄多孔的壳的空 microspheres，另外一个是在更高的 PLGA 集中下面的像红血球的 microspheres。包括有薄多孔的壳的多孔的、空核心的 microspheres 的三种类型(表示了由在摘要空) 并且稳固的结构最后被选择为在 vitro 药版本测试。牛的浆液白朊(BSA ) 被选择为模型药并且在 microspheres 以内包含。多孔、空、稳固的 microspheres 的 BSA 封装效率是分别地 90.4% ， 79.8% 和 0。并且最终的积聚的版本是分别地 74.5% ， 58.9% 和 0。多孔的 microspheres 的版本率比空 microspheres 的慢得多。实验结果显示有不同多孔的结构的 microspheres 在控制药版本行为显示出大潜力。" @default.
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- W3142482852 date "2015-01-01" @default.
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- W3142482852 title "Preparation of PLGA Microspheres with Different Porous Morphologies" @default.
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