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- W3142495478 abstract "Objective To investigate the effects of menthol on the proliferation and motility of androgen-independent prostate cancer DU145 cells. Methods The expressions of TRPM8 and TRPA1 in DU145 cells were detected using RT-PCR, immunohistochemical assay and Western blot assay; MTT assay and scratch motility assay were performed to investigate the effects of menthol on the proliferation and motility of DU145 cells and cell cycle and cell apoptosis were also detected by flow cytometry. Results The outcome of RT-PCR, immunohistochemical assay and Western blot assay indicated that DU145 cells have a remarkable expression of TRPM8 but dose not express TRPA1. Compared with non-menthol-treated cells, there is a significant increase in G0/G1 phase cell fraction after 24, 48 and 72 h 100 μmol/L menthol treatment (49.12%±1.92% vs 61.71%±2.70%, 77.65%±1.63%, 71.81%±2.46%, P0.05, P0.01), and menthol could inhibit the cell growth (P0.05) and cell motility (P0.05) and it failed to induce cell apoptosis. Conclusions TRPM8 may serve as important target for the treatment of prostate cancer and TRPM8 activation is more pragmatic than TRPM8 gene therapy for those androgen-independent prostate cancers with high level expression of TRPM8. Thus, menthol is a useful compound for future development as an anticancer agent." @default.
- W3142495478 created "2021-04-13" @default.
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- W3142495478 date "2012-01-01" @default.
- W3142495478 modified "2023-09-24" @default.
- W3142495478 title "Menthol inhibits the proliferation and motility of prostate cancer DU145 cells" @default.
- W3142495478 hasPublicationYear "2012" @default.
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