Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142509805> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- W3142509805 endingPage "8504" @default.
- W3142509805 startingPage "8491" @default.
- W3142509805 abstract "Liver zonation,the spatial separation of the immense spectrum of different metabolic pathways along the liver sinusoids,is fundamental for proper functioning of this organ.Recent progress in elucidating localization and interactions of different metabolic pathways by using'omics'techniques and novel approaches to couple them with refined spatial resolution and in characterizing novel master regulators of zonation by using transgenic mice has created the basis for a deeper understanding of core mechanisms of zonation and their impact on liver physiology,pathology and metabolic diseases.This review summarizes the fascinating technical achievements for investigating liver zonation and the elucidation of an emerging network of master regulators of zonation that keep the plethora of interrelated and sometimes opposing functions of the liver in balance with nutritional supply and specific requirements of the entire body.In addition,a brief overview is given on newly described zonated functions and novel details on how diverse the segmentation of metabolic zonation may be.From these facts and developments a few fundamental principles are inferred which seem to rule zonation of liver parenchyma.In addition,we identify important questions that still need to be answered as well as interesting fields of research such as the connection of zonation with circadian rhythm and gender dimorphism which need to be pushed further,in order to improve our understanding of metabolic zonation.Finally,an outlook is given on how disturbance of liver zonation and its regulation may impact on liver pathology and the development of metabolic diseases." @default.
- W3142509805 created "2021-04-13" @default.
- W3142509805 creator A5004465284 @default.
- W3142509805 creator A5023102556 @default.
- W3142509805 creator A5041330198 @default.
- W3142509805 creator A5075259038 @default.
- W3142509805 date "2014-01-01" @default.
- W3142509805 modified "2023-09-26" @default.
- W3142509805 title "Liver zonation: Novel aspects of its regulation and its impact on homeostasis" @default.
- W3142509805 hasPublicationYear "2014" @default.
- W3142509805 type Work @default.
- W3142509805 sameAs 3142509805 @default.
- W3142509805 citedByCount "0" @default.
- W3142509805 crossrefType "journal-article" @default.
- W3142509805 hasAuthorship W3142509805A5004465284 @default.
- W3142509805 hasAuthorship W3142509805A5023102556 @default.
- W3142509805 hasAuthorship W3142509805A5041330198 @default.
- W3142509805 hasAuthorship W3142509805A5075259038 @default.
- W3142509805 hasConcept C169760540 @default.
- W3142509805 hasConcept C41008148 @default.
- W3142509805 hasConcept C60644358 @default.
- W3142509805 hasConcept C70721500 @default.
- W3142509805 hasConcept C86803240 @default.
- W3142509805 hasConceptScore W3142509805C169760540 @default.
- W3142509805 hasConceptScore W3142509805C41008148 @default.
- W3142509805 hasConceptScore W3142509805C60644358 @default.
- W3142509805 hasConceptScore W3142509805C70721500 @default.
- W3142509805 hasConceptScore W3142509805C86803240 @default.
- W3142509805 hasIssue "26" @default.
- W3142509805 hasLocation W31425098051 @default.
- W3142509805 hasOpenAccess W3142509805 @default.
- W3142509805 hasPrimaryLocation W31425098051 @default.
- W3142509805 hasRelatedWork W2013232839 @default.
- W3142509805 hasRelatedWork W2014298366 @default.
- W3142509805 hasRelatedWork W2021747008 @default.
- W3142509805 hasRelatedWork W2066873436 @default.
- W3142509805 hasRelatedWork W2083428681 @default.
- W3142509805 hasRelatedWork W2162790428 @default.
- W3142509805 hasRelatedWork W3012835201 @default.
- W3142509805 hasRelatedWork W3092049978 @default.
- W3142509805 hasRelatedWork W3120569057 @default.
- W3142509805 isParatext "false" @default.
- W3142509805 isRetracted "false" @default.
- W3142509805 magId "3142509805" @default.
- W3142509805 workType "article" @default.