Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142526289> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3142526289 abstract "Protein-coding genes in the trypanosome genome are organized in polycistronic transcription units (PTUs). How RNA Polymerase II (Pol II) initiates PTU transcription has not been resolved and the current model favors initiation driven by chromatin epigenetic marks, rather than core-promoters. Here, we identify sequence-specific promoters by functional characterization of Pol II accumulation peaks identified by ChIP-Seq. Sequences located between oppositely orientated PTUs contained two independent and distinct promoters, each driving unidirectional transcription. Detailed analysis identified a 75-bp promoter necessary and sufficient to drive full reporter expression and containing functional motifs. Analysis of further promoters suggested activity and initiation is regulated and transcription-pattern is either focused or dispersed. In contrast to previous model of unregulated and promoter-independent transcription initiation, sequence-specific promoters determine the initiation of Pol II transcription of protein-coding genes in trypanosomes. These findings resolve the discrepancy between trypanosomes and other eukaryotes in how Pol II initiates protein-coding gene transcription and provide a new framework to events underlying eukaryotic transcription evolution." @default.
- W3142526289 created "2021-04-13" @default.
- W3142526289 creator A5010864918 @default.
- W3142526289 creator A5012085833 @default.
- W3142526289 creator A5026892651 @default.
- W3142526289 creator A5026923700 @default.
- W3142526289 creator A5038211308 @default.
- W3142526289 creator A5046892435 @default.
- W3142526289 creator A5059482371 @default.
- W3142526289 creator A5089028569 @default.
- W3142526289 creator A5089854838 @default.
- W3142526289 date "2021-01-01" @default.
- W3142526289 modified "2023-09-23" @default.
- W3142526289 title "Identification of the Elusive Core Promoters Driving Polycistronic Transcription by RNA Polymerase II in Trypanosomes" @default.
- W3142526289 cites W1894335898 @default.
- W3142526289 cites W2064210252 @default.
- W3142526289 cites W2067728537 @default.
- W3142526289 cites W2111565312 @default.
- W3142526289 cites W2143266139 @default.
- W3142526289 cites W2147875291 @default.
- W3142526289 cites W2157009395 @default.
- W3142526289 cites W2320011971 @default.
- W3142526289 cites W2754259340 @default.
- W3142526289 doi "https://doi.org/10.2139/ssrn.3809988" @default.
- W3142526289 hasPublicationYear "2021" @default.
- W3142526289 type Work @default.
- W3142526289 sameAs 3142526289 @default.
- W3142526289 citedByCount "0" @default.
- W3142526289 crossrefType "journal-article" @default.
- W3142526289 hasAuthorship W3142526289A5010864918 @default.
- W3142526289 hasAuthorship W3142526289A5012085833 @default.
- W3142526289 hasAuthorship W3142526289A5026892651 @default.
- W3142526289 hasAuthorship W3142526289A5026923700 @default.
- W3142526289 hasAuthorship W3142526289A5038211308 @default.
- W3142526289 hasAuthorship W3142526289A5046892435 @default.
- W3142526289 hasAuthorship W3142526289A5059482371 @default.
- W3142526289 hasAuthorship W3142526289A5089028569 @default.
- W3142526289 hasAuthorship W3142526289A5089854838 @default.
- W3142526289 hasConcept C101762097 @default.
- W3142526289 hasConcept C104317684 @default.
- W3142526289 hasConcept C138885662 @default.
- W3142526289 hasConcept C150194340 @default.
- W3142526289 hasConcept C172768829 @default.
- W3142526289 hasConcept C179926584 @default.
- W3142526289 hasConcept C196117886 @default.
- W3142526289 hasConcept C2776449523 @default.
- W3142526289 hasConcept C41895202 @default.
- W3142526289 hasConcept C54355233 @default.
- W3142526289 hasConcept C64350747 @default.
- W3142526289 hasConcept C67705224 @default.
- W3142526289 hasConcept C70721500 @default.
- W3142526289 hasConcept C70916841 @default.
- W3142526289 hasConcept C86803240 @default.
- W3142526289 hasConceptScore W3142526289C101762097 @default.
- W3142526289 hasConceptScore W3142526289C104317684 @default.
- W3142526289 hasConceptScore W3142526289C138885662 @default.
- W3142526289 hasConceptScore W3142526289C150194340 @default.
- W3142526289 hasConceptScore W3142526289C172768829 @default.
- W3142526289 hasConceptScore W3142526289C179926584 @default.
- W3142526289 hasConceptScore W3142526289C196117886 @default.
- W3142526289 hasConceptScore W3142526289C2776449523 @default.
- W3142526289 hasConceptScore W3142526289C41895202 @default.
- W3142526289 hasConceptScore W3142526289C54355233 @default.
- W3142526289 hasConceptScore W3142526289C64350747 @default.
- W3142526289 hasConceptScore W3142526289C67705224 @default.
- W3142526289 hasConceptScore W3142526289C70721500 @default.
- W3142526289 hasConceptScore W3142526289C70916841 @default.
- W3142526289 hasConceptScore W3142526289C86803240 @default.
- W3142526289 hasLocation W31425262891 @default.
- W3142526289 hasOpenAccess W3142526289 @default.
- W3142526289 hasPrimaryLocation W31425262891 @default.
- W3142526289 hasRelatedWork W1520612026 @default.
- W3142526289 hasRelatedWork W1971465291 @default.
- W3142526289 hasRelatedWork W1991327363 @default.
- W3142526289 hasRelatedWork W2030907738 @default.
- W3142526289 hasRelatedWork W2082395806 @default.
- W3142526289 hasRelatedWork W2094385715 @default.
- W3142526289 hasRelatedWork W2111612750 @default.
- W3142526289 hasRelatedWork W2218142690 @default.
- W3142526289 hasRelatedWork W4210963035 @default.
- W3142526289 hasRelatedWork W50051891 @default.
- W3142526289 isParatext "false" @default.
- W3142526289 isRetracted "false" @default.
- W3142526289 magId "3142526289" @default.
- W3142526289 workType "article" @default.